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Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
A multiprotein complex containing TACC3, clathrin and other proteins has been implicated in mitotic spindle stability. To disrupt this complex in an anti-cancer context, we need to understand its composition and how it interacts with microtubules. In
Autor:
Jan G. Ruppert, Yasusei Kudo, William C. Earnshaw, Rieko Arakaki, Michele Pagano, Hidehiko Kawai, Naozumi Ishimaru, Koichi Tsuneyama, Takaaki Tsunematsu
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
During mitosis, the chromosomal passenger complex (CPC) ensures the faithful transmission of the genome. The CPC is composed of the enzymatic component Aurora B (AURKB) and the three regulatory and targeting components borealin, INCENP, and survivin
Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting
Publikováno v:
Evans, A J, Daly, J, Anuar, A N K, Simonetti, B & Cullen, P J 2020, ' Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting ', Journal of Cell Science, vol. 133, jcs246033 . https://doi.org/10.1242/jcs.246033
Journal of Cell Science
article-version (VoR) Version of Record
Journal of Cell Science
article-version (VoR) Version of Record
Human retromer, a heterotrimer of VPS26 (VPS26A or VPS26B), VPS35 and VPS29, orchestrates the endosomal retrieval of internalised cargo and promotes their cell surface recycling, a prototypical cargo being the glucose transporter GLUT1 (also known as
Autor:
Daphne M. van Elsland, Sabine A.G. Cuijpers, William C. Earnshaw, Jan G. Ruppert, Alfred C.O. Vertegaal, Edwin Willemstein
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
Journal of Cell Science, 133(14). COMPANY BIOLOGISTS LTD
Cuijpers, S, Willemstein, E, Ruppert, J, van Elsland, D M, Earnshaw, B & Vertegaal, A C O 2020, ' Chromokinesin KIF4A teams up with Stathmin 1 to regulate abscission in a SUMO-dependent manner ', Journal of Cell Science . https://doi.org/10.1242/jcs.248591
article-version (VoR) Version of Record
Journal of Cell Science, 133(14). COMPANY BIOLOGISTS LTD
Cuijpers, S, Willemstein, E, Ruppert, J, van Elsland, D M, Earnshaw, B & Vertegaal, A C O 2020, ' Chromokinesin KIF4A teams up with Stathmin 1 to regulate abscission in a SUMO-dependent manner ', Journal of Cell Science . https://doi.org/10.1242/jcs.248591
Cell division ends when two daughter cells physically separate via abscission, the cleavage of the intercellular bridge. It is not clear how the anti-parallel microtubule bundles bridging daughter cells are severed. Here, we present a novel abscissio
Autor:
Li, Dan, Fu, Shaozu, Wu, Zhengqian, Yang, Wenping, Ru, Yi, Shu, Hongbing, Liu, Xiangtao, Zheng, Haixue
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Transcription factor IRF3-mediated type I interferon induction plays a role in antiviral innate immunity. However, mechanisms for the control and regulation of IRF3 nuclear import remain largely unknown. We have identified DEAD box polypeptide 56 (DD
Autor:
Demetriadou, Anthi, Morales-Sanfrutos, Julia, Nearchou, Marianna, Baba, Otto, Kyriacou, Kyriacos, Tate, Edward W., Drousiotou, Anthi, Petrou, Petros P.
Publikováno v:
Journal of Cell Science
Starch binding domain-containing protein 1 (Stbd1) is a carbohydrate-binding protein that has been proposed to be a selective autophagy receptor for glycogen. Here, we show that mouse Stbd1 is a transmembrane endoplasmic reticulum (ER)-resident prote
Publikováno v:
J Cell Sci
Epithelial cells, such as liver-resident hepatocytes, rely heavily on the Rab family of small GTPases to perform membrane trafficking events that dictate cell physiology and metabolism. Not surprisingly, disruption of several Rab proteins can manifes
Autor:
Kuldeep Verma, Sivaram V. S. Mylavarapu, Rajaiah Pergu, Kumari Pushpa, Harsh Kumar, Amrita Kumari
Publikováno v:
Journal of Cell Science
Cytokinesis is the final step of cell division following chromosome segregation that generates two daughter cells. The conserved exocyst complex is required for scission of the intercellular cytokinetic bridge, although the molecular mechanisms it em
Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing
Autor:
Bina Prajapati, Mikko J. Frilander, Jori Virtanen, Tiina Viita, Maria K. Vartiainen, Salla Kyheröinen, Markku Varjosalo
Publikováno v:
Journal of Cell Science
In addition to its essential functions within the cytoskeleton, actin also localizes to the cell nucleus, where it is linked to many important nuclear processes from gene expression to maintenance of genomic integrity. However, the molecular mechanis
Autor:
Maria Rödiger, Dmytro Puchkov, Jan Schmoranzer, Gabrielle Capin, Oliver Daumke, Niclas Gimber, Ilka Wilhelmi, Martin Lehmann, Saif Mohd, Michael Krauss, Claudia Gras, Kyungyeun Song, Annette Schürmann
Publikováno v:
Journal of Cell Science
Compartmentalization of membrane transport and signaling processes is of pivotal importance to eukaryotic cell function. While plasma membrane compartmentalization and dynamics are well known to depend on the scaffolding function of septin GTPases, t