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Autor:
Hyun Kyoung Lee, Xiaoyun Ding, Chih-Yen Wang, Carlo D. Cristobal, Qi Ye, Zheng Chen, Diego Cortes, Juyeon Jo
Publikováno v:
J Cell Sci
Wnt signaling plays a critical role in development across species and is dysregulated in a host of human diseases. A key step in signal transduction is the formation of Wnt receptor signalosomes, where a large number of components translocate to the
Autor:
Erkut Ilaslan, Bogna Kuczynska, Maciej J Smialek, Damian M. Janecki, Jadwiga Jaruzelska, Kamila Kusz-Zamelczyk, Marcin Sajek
Publikováno v:
Journal of Cell Science.
Regulation of proliferation, apoptosis and cell cycle is crucial for the physiology of germ cells. Their malfunction contributes to infertility and germ cell tumours. Kinesin KIF18A is an important regulator of those processes in animal germ cells. P
Autor:
Andrew J. Haak, Huihuang Yan, Zhenqing Ye, Giovanni Ligresti, Daniel J. Tschumperlin, Nunzia Caporarello, Kyoung Moo Choi, Xaralabos Varelas, Tamas Ordog, Dakota L. Jones
Publikováno v:
J Cell Sci
Tissue fibrosis is a chronic disease driven by persistent fibroblast activation that has recently been linked to epigenetic modifications. Here, we screened a small library of epigenetic small-molecule modulators to identify compounds capable of inhi
Autor:
Wei Hong Toh, Steve K. Dower, Jenny Chia, Gregory T. Bass, Anne M Verhagen, Paul A. Gleeson, Ismail S. Mahmoud, Jade Louber
Publikováno v:
Journal of Cell Science. 133
The neonatal Fc receptor (FcRn) rescues albumin and IgG from degradation following endocytosis and thereby extends the half-life of these plasma proteins. However, the pathways for the uptake of these soluble FcRn ligands, and the recycling itinerary
Publikováno v:
J Cell Sci
Low-density lipoprotein (LDL) deposition, aggregation and retention in the endothelial sub-intima are critical initiating events during atherosclerosis. Macrophages digest aggregated LDL (agLDL) through a process called exophagy. High-density lipopro
Publikováno v:
Journal of cell science. 133(5)
A fundamental question in biology is how single cells can reliably produce progeny of different cell types. Notch signalling frequently facilitates fate determination. Asymmetric cell division (ACD) often controls segregation of Notch signalling by i
Autor:
Stephen A. Ainger, Anna Ehmann, Catherine Lanagan, Brian Gabrielli, Richard A. Sturm, Alexander J. Stevenson, Dubravka Skalamera
Publikováno v:
Journal of cell science. 132(24)
Melanocytic cell interactions are integral to skin homeostasis, and affect the outcome of multiple diseases, including cutaneous pigmentation disorders and melanoma. By using automated-microscopy and machine-learning-assisted morphology analysis of p
Publikováno v:
J Cell Sci
The endocytic protein EHD1 plays an important role in ciliogenesis by facilitating fusion of the ciliary vesicle and removal of CP110 (also known as CCP110) from the mother centriole, as well as removal of Cep215 (also known as CDK5RAP2) from centrio
Autor:
CX Maracle, Jan Piet van Hamburg, Henric Olsson, Sander W. Tas, Kim C. M. Jeucken, Elisabeth Israelsson, P Kucharzewska, Mark Furber
Publikováno v:
Journal of cell science, 132(7). Company of Biologists Ltd
NF-κB-inducing kinase (NIK; also known as MAP3K14) is a central regulator of non-canonical NF-κB signaling in response to stimulation of TNF receptor superfamily members, such as the lymphotoxin-β receptor (LTβR), and is implicated in pathologica
Autor:
Yong Zhou, Christian M. Garrido, Robert J. Capon, Walaa E Kattan, Kwang-Jin Cho, Lingxiao Tan, John F. Hancock, Pratik Neupane
Publikováno v:
J Cell Sci
The primary site for KRAS signaling is the inner leaflet of the plasma membrane (PM). We previously reported that oxanthroquinone G01 (G01) inhibited KRAS PM localization and blocked KRAS signaling. In this study, we identified acylpeptide hydrolase