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Autor:
Lucian B. Tomaz, Bernard A. Liu, null Meroshini M, Sheena L. M. Ong, Ee Kim Tan, Nicholas S. Tolwinski, Christopher S. Williams, Anne-Claude Gingras, Marc Leushacke, N. Ray Dunn
Publikováno v:
Journal of Cell Science. 135
The gene mutated in colorectal cancer (MCC) encodes a coiled-coil protein implicated, as its name suggests, in the pathogenesis of hereditary human colon cancer. To date, however, the contributions of MCC to intestinal homeostasis and disease remain
Publikováno v:
Journal of Cell Science. 135
A large group of keratin genes (n=54 in the human genome) code for intermediate filament (IF)-forming proteins and show differential regulation in epithelial cells and tissues. Keratin expression can be highly informative about the type of epithelial
Autor:
Ignasi Casanellas, Hongkai Jiang, Carolyn M. David, Yolanda Vida, Ezequiel Pérez-Inestrosa, Josep Samitier, Anna Lagunas
Publikováno v:
Journal of cell science. 135(22)
Effective cartilage development relies on the successful formation of mesenchymal cell condensates. Mesenchymal condensation is a prevalent morphogenetic transition, which involves the upregulation of the adhesive extracellular glycoprotein fibronect
Publikováno v:
Journal of Cell Science. 135
Cardiomyocyte elongation and alignment, a critical step in cardiomyocyte maturation starting from the perinatal stage, is crucial for formation of the highly organized intra- and inter-cellular structures for spatially and temporally ordered contract
Publikováno v:
Journal of Cell Science. 135
Muscle stem (satellite) cells express Pax7, a key transcription factor essential for satellite cell maintenance and adult muscle regeneration. We identify the corepressor transducin-like enhancer of split-4 (TLE4) as a Pax7 interaction partner expres
Autor:
Vinay Kumar Dubey, Souradeep R. Sarkar, Vairavan Lakshmanan, Rimple Dalmeida, Akash Gulyani, Dasaradhi Palakodeti
Publikováno v:
Journal of cell science. 135(20)
Extracellular matrix (ECM) is an important component of stem cell niche. Remodeling of ECM mediated by ECM regulators, such as matrix metalloproteinases (MMPs) plays a vital role in stem cell function. However, the mechanisms that modulate the functi
Publikováno v:
Journal of Cell Science. 134
Nucleoporins regulate nuclear transport and are also involved in DNA damage, repair, cell cycle, chromatin organization and gene expression. Here, we studied the role of nucleoporin Nup93 and the chromatin organizer CTCF in regulating expression of t
Autor:
Virginie Vives, Guillaume Bompard, Justine Maurin, Pauline Marie, Anne Blangy, David Guérit, Anne Morel
Publikováno v:
Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2020, 133 (13), pp.jcs244798. ⟨10.1242/jcs.244798⟩
Journal of Cell Science, 2020, 133 (13), pp.jcs244798. ⟨10.1242/jcs.244798⟩
Journal of Cell Science, Company of Biologists, 2020, 133 (13), pp.jcs244798. ⟨10.1242/jcs.244798⟩
Journal of Cell Science, 2020, 133 (13), pp.jcs244798. ⟨10.1242/jcs.244798⟩
Osteoclasts are giant multinucleated myeloid cells specialized for bone resorption, which is essential for the preservation of bone health throughout life. The activity of osteoclasts relies on the typical organization of osteoclast cytoskeleton comp
Autor:
Angelos Papadopoulos, Varvara Chalmantzi, Yiannis Kalaidzidis, Marko Hyvönen, Sofia Bellou, Athena Kyrkou, Carol Murphy, Eleni Bagli, Maria Markou, Eleftherios Kostaras, Theodore Fotsis, Nikoleta Kostopoulou, Ekaterini Panopoulou
Publikováno v:
Journal of cell science. 134(13)
Ligand–receptor complexes formed at the plasma membrane are internalised via various endocytic pathways that influence the ultimate signalling output by regulating the selection of interaction partners by the complex along the trafficking route. We
Autor:
Parastoo Boroumand, Amira Klip
Publikováno v:
Journal of cell science. 133(5)
The bone marrow is a spatially restricted niche, housing cells of the hematopoietic and mesenchymal lineages in various hierarchical commitment states. Although highly localized, cells within this niche are also subject to regulation by environmental