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Publikováno v:
Journal of Cell Science. 131
Glycosphingolipids (GSLs) are ubiquitous components of eukaryotic plasma membranes that consist of a ceramide backbone linked to a glycan moiety. Both the ceramide and the glycan parts of GSLs display structural variations that result in a remarkable
Publikováno v:
Journal of cell science. 130(22)
The PIDDosome is often used as the alias for a multi-protein complex that includes the p53-induced death domain protein 1 (PIDD1), the bipartite linker protein CRADD (also known as RAIDD) and the pro-form of an endopeptidase belonging to the caspase
Autor:
Marie Ennen, Diana Langer, Dominique Kobi, Stéphanie Le Gras, Irwin Davidson, Tao Ye, Sylvia Urban
Publikováno v:
Journal of Cell Science. 128:2303-2318
Mouse embryonic stem cells (ESCs) treated with all-trans retinoic acid differentiate into a homogenous population of glutamatergic neurons. Although differentiation is initiated through activation of target genes by the retinoic acid receptors, the d
Publikováno v:
Journal of Cell Science
Photoactivation allows one to pulse-label molecules and obtain quantitative data about their behavior. We have devised a new modeling-based analysis for photoactivatable actin experiments that simultaneously measures properties of monomeric and filam
Publikováno v:
Journal of Cell Science.
Ras signaling is tightly regulated during neural stem cell (NSC) differentiation, and defects in this pathway result in aberrant brain development. However, the mechanism regulating Ras signaling during NSC differentiation was unknown. Here, we show
Autor:
Fumihiko Okumura, Tadashi Ariga, Takeshi Kondo, Shigetsugu Hatakeyama, Tomonobu Sato, Satoshi Kano
Publikováno v:
Journal of Cell Science. 124:3492-3502
Retinoic acid (RA), a metabolite of vitamin A, plays versatile roles in development, differentiation, cell cycles and regulation of apoptosis by regulating gene transcription through nuclear receptor activation. Ubiquitinylation, which is one of the
Autor:
Girolama La Mantia, Ygal Haupt, Luisa Guerrini, Eitan Shaulian, Shira Anzi, Teresa Lopardo, Francesco Galli, Viola Calabrò, Mariangela Rossi, Osnat Alsheich-Bartok, Marco De Simone, Yuri D'Alessandra
Publikováno v:
Journal of Cell Science. 123:2423-2433
Tight control of p63 protein levels must be achieved under differentiation or apoptotic conditions. Here, we describe a new regulatory pathway for the DeltaNp63 alpha protein. We found that MDM2 binds DeltaNp63 alpha in the nucleus promoting its tran
Autor:
Teruko Danjyo, Yoshiki Sasai, Hanako Ikeda, Yasuhiko Hirami, Fumitaka Osakada, Kiichi Watanabe, Zi-Bing Jin, Masayo Takahashi
Publikováno v:
Journal of Cell Science. 122:3169-3179
The use of stem-cell therapy to treat retinal degeneration holds great promise. However, definitive methods of retinal differentiation that do not depend on recombinant proteins produced in animal or Escherichia coli cells have not been devised. Here
Autor:
Roberta Squecco, Francesca Bini, Giorgia Luciani, Elisabetta Meacci, Sandra Zecchi-Orlandini, Francesca Sbrana, Flaminia Chellini, Chiara Sassoli, Lucia Formigli, Maria Martinesi, Fabio Francini
Publikováno v:
Journal of Cell Science. 122:1322-1333
Transient receptor potential canonical (TRPC) channels provide cation and Ca2+ entry pathways, which have important regulatory roles in many physio-pathological processes, including muscle dystrophy. However, the mechanisms of activation of these cha
Publikováno v:
Journal of Cell Science. 121:3561-3569
Kazrin is an evolutionarily conserved protein that is upregulated during keratinocyte terminal differentiation. Kazrin localizes to desmosomes and binds the epidermal cornified envelope protein periplakin. Kazrin overexpression in human epidermal ker