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Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Centromeres are chromosomal regions that serve as sites for kinetochore formation and microtubule attachment, processes that are essential for chromosome segregation during mitosis. Centromeres are almost universally defined by the histone variant CE
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The WAVE regulatory complex (WRC) is the main activator of the Arp2/3 complex, promoting lamellipodial protrusions in migrating cells. The WRC is basally inactive but can be activated by Rac1 and phospholipids, and through phosphorylation. However, t
Autor:
Lina Abdelmoti, Malathy Palayam, Rebecca Norcross, Eun Ryoung Jang, Patricia G. Wilson, Emilia Galperin
Publikováno v:
J Cell Sci
The ERK1/2 (also known as MAPK3 and MAPK1, respectively) signaling pathway is critical in organismal development and tissue morphogenesis. Deregulation of this pathway leads to congenital abnormalities with severe developmental dysmorphisms. The core
Desmosome dualism – most of the junction is stable, but a plakophilin moiety is persistently dynamic
Autor:
David Liebl, Graham D. Wright, Christoph Ballestrem, David R Garrod, Jaron Liu, Rogerio Alves de Almeida, Henri Huppert, Bian Yanes, E. Birgitte Lane, Judith B Fülle
Publikováno v:
J Cell Sci
Desmosomes, strong cell–cell junctions of epithelia and cardiac muscle, link intermediate filaments to cell membranes and mechanically integrate cells across tissues, dissipating mechanical stress. They comprise five major protein classes – desmo
Autor:
Lilach Sheiner, Jeremy G. Wideman, Christopher J. Tonkin, Marco Biddau, Jana Ovciarikova, Clare R. Harding, Erica S. Martins-Duarte, Alessandro D. Uboldi, Natalia Mallo, Mary-Louise Wilde, Stephan C Baehr, Leandro Lemgruber
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The voltage-dependent anion channel (VDAC) is a ubiquitous channel in the outer membrane of the mitochondrion with multiple roles in protein, metabolite and small molecule transport. In mammalian cells, VDAC protein, as part of a larger complex inclu
Publikováno v:
J Cell Sci
Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) play a central role in regulating intracellular Ca2+ signals in response to a variety of internal and external cues. Dysregulation of IP3R signaling is the underlying cause for numerous pathologica
Autor:
Audrey Brenot, Maria Clarke, Patrick Pence, Priscilla Y. Hwang, Craig E. Barcus, Gregory D. Longmore, Vasilios Morikis
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Both tumor cell-intrinsic signals and tumor cell-extrinsic signals from cells within the tumor microenvironment influence tumor cell dissemination and metastasis. The fibrillar collagen receptor tyrosine kinase (RTK) discoidin domain receptor 2 (DDR2
Autor:
Petra Jakobs, Uwe Kirchhefer, Dominique Manikowski, Kay Grobe, Jurij Froese, Kristina Ehring, Jonas Goretzko, Fabian Gude, Ursula Rescher
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The Sonic hedgehog (Shh) pathway controls embryonic development and tissue homeostasis after birth. Long-standing questions about this pathway include how the dual-lipidated, firmly plasma membrane-associated Shh ligand is released from producing cel
Autor:
Stephen C. Bunnell, Keith P. Eidell, Alenka Lovy, Ken Nguyen, Frank A Scangarello, Michael J. Ophir, Maria-Cristina Seminario, Hayley I. Muendlein, Nicholas R. Sylvain
Publikováno v:
J Cell Sci
Integrin engagement within the immune synapse enhances T cell activation, but our understanding of this process is incomplete. In response to T cell receptor (TCR) ligation, SLP-76 (LCP2), ADAP (FYB1) and SKAP55 (SKAP1) are recruited into microcluste
EVI/WLS function is regulated by ubiquitylation and is linked to ER-associated degradation by ERLIN2
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
WNT signalling is important for development in all metazoans and is associated with various human diseases. The ubiquitin–proteasome system (UPS) and regulatory endoplasmic reticulum-associated degradation (ERAD) have been implicated in the product