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pro vyhledávání: ''
Autor:
Andrew J. Haak, Huihuang Yan, Zhenqing Ye, Giovanni Ligresti, Daniel J. Tschumperlin, Nunzia Caporarello, Kyoung Moo Choi, Xaralabos Varelas, Tamas Ordog, Dakota L. Jones
Publikováno v:
J Cell Sci
Tissue fibrosis is a chronic disease driven by persistent fibroblast activation that has recently been linked to epigenetic modifications. Here, we screened a small library of epigenetic small-molecule modulators to identify compounds capable of inhi
Autor:
Wei Hong Toh, Steve K. Dower, Jenny Chia, Gregory T. Bass, Anne M Verhagen, Paul A. Gleeson, Ismail S. Mahmoud, Jade Louber
Publikováno v:
Journal of Cell Science. 133
The neonatal Fc receptor (FcRn) rescues albumin and IgG from degradation following endocytosis and thereby extends the half-life of these plasma proteins. However, the pathways for the uptake of these soluble FcRn ligands, and the recycling itinerary
Autor:
Yong Zhou, Christian M. Garrido, Robert J. Capon, Walaa E Kattan, Kwang-Jin Cho, Lingxiao Tan, John F. Hancock, Pratik Neupane
Publikováno v:
J Cell Sci
The primary site for KRAS signaling is the inner leaflet of the plasma membrane (PM). We previously reported that oxanthroquinone G01 (G01) inhibited KRAS PM localization and blocked KRAS signaling. In this study, we identified acylpeptide hydrolase
Autor:
Christina Kyrousi, Marina Arbi, Konstantina Kaplani, Argyro Kalogeropoulou, Natasa Josipovic, Zoi Lygerou, Vladimir Benes, Stavros Taraviras, Georgia Lokka, Dimitrios Gkikas, Ioannis Loukas, Athanasia Mizi, Maria-Eleni Lalioti, Panagiotis K. Politis, Theodore Georgomanolis, Argyris Papantonis
Publikováno v:
Journal of cell science. 132(11)
A distinct combination of transcription factors elicits the acquisition of a specific fate and the initiation of a differentiation program. Multiciliated cells (MCCs) are a specialized type of epithelial cells that possess dozens of motile cilia on t
Publikováno v:
Journal of Cell Science.
Intermediate filament protein keratin 8 (K8) binds to heat shock protein 70 (Hsp70) and p38 MAPK, and is phosphorylated at Ser74 by p38α (MAPK14, hereafter p38). However, a p38 binding site on K8 and the molecular mechanism of K8-p38 interaction rel
Autor:
Hikaru Yamamoto, Masatoshi Maki, Emi Tokuda, Kazuya Tsujita, Toshiki Itoh, Imen Jebri, Junya Hasegawa, Hideki Shibata
Publikováno v:
Journal of Cell Science.
Ubiquitinated membrane proteins such as epidermal growth factor receptor (EGFR) are delivered to early endosomes and then sorted to lysosomes via multivesicular bodies (MVBs) for degradation. The regulatory mechanism underlying formation of intralume
Autor:
Joseph D. Mueller, Guanghao Liu, Chad J. Leugers, Yohan Kim, Julie A. Schneider, Gloria Lee, Meghan B. Francis, Marco M. Hefti
Publikováno v:
J Cell Sci
Microtubule-associated protein tau, an integral component of neurofibrillary tangles, interacts with a variety of signaling molecules. Previously, our laboratory reported that nerve growth factor (NGF)-induced MAPK activation in a PC12-derived cell l
Autor:
Hiroshi Hanafusa, Kozo Kaibuchi, Naoki Hisamoto, Kyoko Shirakabe, Kunihiro Matsumoto, Haruka Ikeda, Tomoki Nishioka, Takuya Yagi
Publikováno v:
Journal of cell science. 132(11)
Ligand-induced activation of epidermal growth factor receptor (EGFR) initiates trafficking events that re-localize the receptor from the cell surface to intracellular endocytic compartments. EGFR-containing endosomes are transported to lysosomes for
Autor:
Sakai, R., Fukuda, R., Unida, S., Aki, M., Ono, Y., Endo, A., Kusumi, S., Koga, D., Fukushima, Toshiaki, Komada, M., Okiyoneda, T.
Publikováno v:
Journal of cell science. 132(3)
Endocytic trafficking is regulated by ubiquitylation (also known as ubiquitination) of cargoes and endocytic machineries. The role of ubiquitylation in lysosomal delivery has been well documented, but its role in the recycling pathway is largely unkn
Publikováno v:
Journal of cell science. 131(10)
Structural analyses of β2 and β3 integrins have revealed that they generally assume a compact bent conformation in the resting state and undergo a global conformational transition involving extension during upregulation of ligand affinity, collecti