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Autor:
Michiel van Gent, Nikolay V. Ogryzko, Tomasz K. Prajsnar, Stephen A. Renshaw, Julia Kolata, Nienke W.M. de Jong, Jos A. G. van Strijp, Kyle D. Buchan, Simon J. Foster
Publikováno v:
Journal of Cell Science. 134
Staphylococcus aureus infects ∼30% of the human population and causes a spectrum of pathologies ranging from mild skin infections to life-threatening invasive diseases. The strict host specificity of its virulence factors has severely limited the a
Publikováno v:
Journal of cell science. 132(23)
The transcription factor Snai2, encoded by the SNAI2 gene, is an evolutionarily conserved C2H2 zinc finger protein that orchestrates biological processes critical to tissue development and tumorigenesis. Initially characterized as a prototypical epit
Autor:
Naama Aviram, Maya Schuldiner
Publikováno v:
Journal of Cell Science. 130:4079-4085
The evolutionary emergence of organelles was a defining process in diversifying biochemical reactions within the cell and enabling multicellularity. However, compartmentalization also imposed a great challenge−the need to import proteins synthesize
Publikováno v:
Journal of cell science. 131(6)
Elevated oxidized stress contributes to lens cataracts, and gap junctions play important roles in maintaining lens transparency. As well as forming gap junctions, connexin (Cx) proteins also form hemichannels. Here, we report a new mechanism whereby
Autor:
Lei Chang, Kavita Shah, George E. Sandusky, Keith Viccaro, Max Jacobsen, Jing Wang, Kumar Nikhil
Publikováno v:
Journal of Cell Science.
We uncovered a crucial role for the Aurora kinase A (AURKA)–Twist1 axis in promoting epithelial-to-mesenchymal transition (EMT) and chemoresistance in pancreatic cancer. Twist1 is the first EMT-specific target of AURKA that was identified using an
Autor:
Shane Austin, Julie St-Pierre
Publikováno v:
Journal of Cell Science. 125:4963-4971
Summary PGC1α is a transcriptional coactivator that is a central inducer of mitochondrial biogenesis in cells. Recent work highlighted that PGC1α can also modulate the composition and functions of individual mitochondria. Therefore, it is emerging
Autor:
Sergio Bondanza, Riccardo Maurelli, Maurizio C. Capogrossi, Anna Lisa Severi, Giuseppe Mesiti, Lavinia Tinaburri, Claudia Scarponi, Fabio Maria Gangi, Liliana Guerra, Elena Dellambra, Cristina Albanesi
Publikováno v:
Journal of Cell Science.
The role of Ras in human skin tumorigenesis induction is still ambiguous. Overexpression of oncogenic Ras causes premature senescence in cultured human cells and hyperplasia in transgenic mice. Here, we investigated whether the oncogenic insult outco
Autor:
Philip S. Low, Kavita Shah, Soumitra Ghosh, C. Venkatesh, Katie Giger, Kuei-Hua Chang, Emmanuel O. Johnson
Publikováno v:
Journal of Cell Science. 125:1204-1216
Aurora A is overexpressed in majority of breast carcinomas. With the exception of BRCA1 and PHLDA1, no oncogenic Aurora A substrates are known in breast cancer. In this study, a chemical genetic approach was used to identify malignant targets of Auro
Autor:
Wei Xiong, Ming Zhou, Hailin Tang, Jian Ma, Qiurong Ye, Ying Zheng, Xiaofang Guo, Min Deng, Qianjin Liao, Yanhong Zhou, Xi Zeng, Guiyuan Li, Xiaoling Li
Publikováno v:
Journal of Cell Science. 124:2997-3005
MicroRNAs (miRNAs) are small noncoding RNAs that are involved in various diseases, including cancer. In the present study, we found that miR-216b was downregulated in nasopharyngeal carcinoma (NPC) cell lines and specimens. Decreased expression of mi
Autor:
Anna-Maria Joseph, Arnold Y. Seo, Debapriya Dutta, Judy C.Y. Hwang, John P. Aris, Christiaan Leeuwenburgh
Publikováno v:
Journal of Cell Science. 123:2533-2542
A decline in mitochondrial function plays a key role in the aging process and increases the incidence of age-related disorders. A deeper understanding of the intricate nature of mitochondrial dynamics, which is described as the balance between mitoch