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Autor:
F. Brad Johnson, Osamu Iwasaki, Andrew V. Kossenkov, Linh Le, Gretchen M. Alicea, Hideki Tanizawa, Ting-Lin B. Yang, Nail Fatkhutdinov, Benjamin G. Bitler, Ken-ichi Noma, Katherine M. Aird, Rugang Zhang
Publikováno v:
The Journal of Cell Biology
In senescence, specific genes encoding secreted factors are excluded from senescence-associated heterochromatin foci, but the mechanisms underlying this senescence-associated secretory phenotype (SASP) are unclear. Aird et al. show that the chromatin
Autor:
Paolo Bianchini, Alessandro Quattrone, Paola Bernabo, Toma Tebaldi, Cecilia Pederzolli, Lorenzo Lunelli, Robert J.C. Gilbert, Andrea Passerini, Gabriella Viero, Alberto Diaspro
Publikováno v:
The journal of cell biology (Online) 208 (2015): 581–596. doi:10.1083/jcb.201406040
info:cnr-pdr/source/autori:Viero G.; Lunelli L.; Passerini A.; Bianchini P.; Gilbert R.J.; Bernabo P.; Tebaldi T.; Diaspro A.; Pederzolli C.; Quattrone A./titolo:Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes/doi:10.1083%2Fjcb.201406040/rivista:The journal of cell biology (Online)/anno:2015/pagina_da:581/pagina_a:596/intervallo_pagine:581–596/volume:208
The Journal of Cell Biology
info:cnr-pdr/source/autori:Viero G.; Lunelli L.; Passerini A.; Bianchini P.; Gilbert R.J.; Bernabo P.; Tebaldi T.; Diaspro A.; Pederzolli C.; Quattrone A./titolo:Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes/doi:10.1083%2Fjcb.201406040/rivista:The journal of cell biology (Online)/anno:2015/pagina_da:581/pagina_a:596/intervallo_pagine:581–596/volume:208
The Journal of Cell Biology
Recurrent supra-ribosomal building blocks separated by ribosome-free mRNA regions form polysomes and reflect cellular translational activity.
Translation is increasingly recognized as a central control layer of gene expression in eukaryotic cell
Translation is increasingly recognized as a central control layer of gene expression in eukaryotic cell
Publikováno v:
The Journal of Cell Biology
Silencing mediator for retinoic acid and thyroid hormone receptor (SMRT) is a transcriptional corepressor that participates in diverse signaling pathways and human diseases. However, regulation of SMRT stability remains largely unexplored. We show th
Autor:
Sarah L. Dallas, C. Adrian Shuttleworth, Stuart A. Cain, Amanda Morgan, Shazia S. Chaudhry, Cay M. Kielty
Publikováno v:
The Journal of Cell Biology
We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) beta1, a powerful cytokine that modulates cell survival and phenotype. Altered TGFbeta signaling is a ma
Autor:
Yukako Oda, Kazutoshi Mori, Tetsuya Okada, Randal J. Kaufman, Hiderou Yoshida, Kazuhiro Nagata
Publikováno v:
The Journal of Cell Biology
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. Components of both productive folding and ER-associated degradation (ERAD) mechanisms are known to be up-reg
Publikováno v:
The Journal of Cell Biology
Mutations in the gene encoding SP-C (surfactant protein C; SFTPC) have been linked to interstitial lung disease (ILD) in children and adults. Expression of the index mutation, SP-C(Deltaexon4), in transiently transfected cells and type II cells of tr
Autor:
Jochen Buck, Kenneth C. Hess, Jeanne Farrell, David R Huron, Margarita Kamenetsky, Jonathan H. Zippin, Lonny R. Levin, Donald A. Fischman
Publikováno v:
The Journal of Cell Biology
Bicarbonate-responsive “soluble” adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of
Autor:
Paul J. Hertzog, Ernst J. Wolvetang, Eiji Hara, Jacques Ghysdael, Elaine Sanij, Martin Rowe, Naoko Ohtani, Stefan Gaubatz, Paul Brennan
Publikováno v:
The Journal of Cell Biology
The p16INK4a–RB pathway plays a critical role in preventing inappropriate cell proliferation and is often targeted by viral oncoproteins during immortalization. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is often present in EBV-as
Autor:
Toshiro Takafuta, Ingrid Kuikman, Sandor S. Shapiro, Arnoud Sonnenberg, Dirk Geerts, Duco Kramer, Arjan van der Flier, Maaike Kreft
Publikováno v:
van der Flier, A, Kuikman, I, Kramer, D, Geerts, D, Kreft, M, Takafuta, T, Shapiro, S S & Sonnenberg, A 2002, ' Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits ', Journal of Cell Biology, vol. 156, no. 2, pp. 361-76 . https://doi.org/10.1083/jcb.200103037
Journal of cell biology, 156(2), 361-376. Rockefeller University Press
Journal of Cell Biology, 156(2), 361-76. Rockefeller University Press
The Journal of Cell Biology
Journal of cell biology, 156(2), 361-376. Rockefeller University Press
Journal of Cell Biology, 156(2), 361-76. Rockefeller University Press
The Journal of Cell Biology
Integrins connect the extracellular matrix with the cell interior, and transduce signals through interactions of their cytoplasmic tails with cytoskeletal and signaling proteins. Using the yeast two-hybrid system, we isolated a novel splice variant (
Autor:
Tohru Kiyono, Miwako Nishizawa, Masaki Inagaki, Hiroyasu Inada, Takashi Momoi, Eriko Fujita, Ichiro Izawa, Toshitada Takahashi
Publikováno v:
The Journal of Cell Biology
Keratin 8 and 18 (K8/18) are the major components of intermediate filament (IF) proteins of simple or single-layered epithelia. Recent data show that normal and malignant epithelial cells deficient in K8/18 are nearly 100 times more sensitive to tumo