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Publikováno v:
Journal of cardiovascular pharmacology. 73(1)
This study was designed to characterize the pharmacological profile of DS37001789, which is a structurally novel piperazine derivative that acts as urotensin II (U-II) receptor antagonist. DS37001789 inhibited [I]-U-II binding to human GPR14, U-II re
Autor:
Masahiko Oka, Mutsumi Kunita-Takanezawa, Katsuya Hirano, Kohtaro Abe, Yukimitsu Kuwabara, Kenji Sunagawa, Yoshitaka Hirooka
Publikováno v:
Scopus-Elsevier
The efficacy of endothelin (ET) receptor antagonist bosentan in patients with severe pulmonary arterial hypertension (PAH) remains limited, partly because its higher doses for potential blockade of ET receptors have never been tested due to liver dys
Autor:
Yadollah Azarmi, Daniel Fadaei Fouladi, Elhameh Nikkhah, Fatemeh Alizadeh, Hossein Babaei, Afsaneh Gharebageri
Publikováno v:
Journal of Cardiovascular Pharmacology. 63:113-119
Xanthine oxidase is an important source of reactive oxygen species; so, it may play a role in the pathogenesis of endothelium dysfunction and its consequences. Allopurinol, a purine analog, is a famous xanthine oxidase inhibitor. This study aimed to
Publikováno v:
Journal of Cardiovascular Pharmacology. 59:37-48
Modulation of the inward rectifier K current (IK1) has profound effect on cardiac excitability and underlies new antiarrhythmic strategies. However, IK1-specific pharmacological tools, especially the selective IK1 agonists, are still lacking in the m
Autor:
Amrit Pal Singh, Randhir Singh Dahiya, Preet Mohinder Singh Bedi, Tajpreet Kaur, Nirmal Singh
Publikováno v:
Journal of Cardiovascular Pharmacology. 56:53-59
The present study has been designed to explore the beneficial effect of rosiglitazone, a peroxisome proliferator activated receptor-gamma agonist, in hyperhomocysteinemia-induced cardiac hypertrophy in rats. The hyperhomocysteinemia was induced in ra
Autor:
Worku Abebe, Mahmood S. Mozaffari
Publikováno v:
Journal of Cardiovascular Pharmacology. 50:590-597
The vascular effects of glucose-intolerance were investigated using the neonatal streptozotocin-treated (nSTZ) rat model. Glucose-intolerance was initiated by administration of STZ (90 mg/kg, IP) into 2-day-old male rats. Aortic reactivity was assess
Autor:
Le Wang, Chao Liu, Mingqi Zheng, Lishuang Ji, Li Tian, Guo-Ping Ma, Qingzhen Zhao, Gang Liu, Yuzhi Zhen, Jianlong Zhai, Linan Duan, Lizhuo Li, Kunshen Liu
Publikováno v:
Journal of cardiovascular pharmacology. 66(3)
BACKGROUND Recent evidence indicates that prednisone can potentiate renal responsiveness to diuretics in heart failure (HF). However, the optimal dose of prednisone is not known. METHOD Thirty-eight patients with symptomatic HF were randomized to rec
Autor:
Kam-ming Chan, R. Jones
Publikováno v:
Journal of Cardiovascular Pharmacology. 43:795-807
This study investigates whether incomplete relaxation of vascular smooth muscle preparations induced by the prostacyclin analogue taprostene is due to partial agonism at prostanoid IP receptors. In the presence of the prostanoid EP4 receptor antagoni
Autor:
Cho Y. Pang, Christopher R. Forrest, Peter C. Neligan, Joan E. Lipa, Ning Huang, Claire E. Black
Publikováno v:
Journal of Cardiovascular Pharmacology. 41:460-467
Vasospasm in the vascular pedicle is a major cause of ischemic necrosis in autogenous skin transplantation (i.e., skin free flap surgery), and the pathophysiology is unclear. The clinical impression is that veins are more susceptible to vasospasm tha
Publikováno v:
Journal of cardiovascular pharmacology. 64(5)
The beta-3 adrenoceptor (β3-AR) protects against the progression of atherosclerosis. However, the specific mechanism of this antiatherosclerotic effect is still not clear. Thus, the aim of this study was to understand the antiatherosclerotic effects