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Publikováno v:
Journal of Cardiovascular Pharmacology
Melatonin, the receptors for which are abundant in the hypothalamic paraventricular nucleus (PVN), can protect the heart from myocardial ischemia–reperfusion (MI/R) injury. The aim of this study was to determine whether the infusion of melatonin in
Autor:
Morteza N Serenjeh, Seyed M M Zarch, Davood Nourabadi, Tourandokht Baluchnejadmojarad, Mehrdad Roghani, Samira Ramazi
Publikováno v:
Journal of cardiovascular pharmacology. 77(2)
Thyroid hormones have a wide range of effects on growth, differentiation, evolution, metabolism, and physiological function of all tissues, including the vascular bed. In this study, the effect of fetal hypothyroidism on impairment of aortic vasorela
Autor:
Timothy M. Eggleston, Benjamin E. Reinking, Sarah E. Haskell, Mitchell E. Kent, Kenneth A. Volk, Robert D. Roghair, Cecilia Lo
Publikováno v:
Journal of cardiovascular pharmacology. 70(2)
Selective serotonin reuptake inhibitors are prescribed to 6%-10% of pregnant women in the United States. Using an intrauterine plus neonatal exposure model to represent exposure throughout human pregnancy, we hypothesized sertraline exposure would im
Autor:
Ze-Yao Tang, Yu-Tao Zhang
Publikováno v:
Journal of Cardiovascular Pharmacology. 63:76-82
Vascular calcification is a common comorbidity in elderly patients with diabetes mellitus or renal insufficiency. A large number of studies have shown that vascular calcification can be induced and accelerated in patients undergoing long-term treatme
Autor:
Tomohiro Osanai, Ken Okumura, Hirofumi Tomita, Yoshihiro Kimura, Takahiko Kinjo, Makoto Tanaka, Hiroaki Ichikawa, Ikuyo Narita, Kimitaka Nishizaki, Tomohiro Tanno
Publikováno v:
Journal of cardiovascular pharmacology. 67(6)
Enhanced renin-angiotensin activity causes hypertension and cardiac hypertrophy. The angiotensin (Ang)-converting enzyme (ACE)2/Ang(1-7)/Mas axis pathway functions against Ang II type 1 receptor (AT1R) signaling. We investigated whether olmesartan (O
Autor:
Jiahong Wang, Kazuki Noda, Takuya Tanaka, Hiroe Toba, Yusuke Yoshifuji, Miyuki Kobara, Tetsuo Nakata, Tatsuya Shiraishi, Junichi Hamada
Publikováno v:
Journal of Cardiovascular Pharmacology. 60:140-149
Reactive oxygen species are exacerbating factors in failing hearts. We examined whether spironolactone, a mineralocorticoid receptor antagonist, provides additional effects to olmesartan, an angiotensin II receptor blocker, on oxidative stress in pos
Publikováno v:
Journal of cardiovascular pharmacology. 67(1)
CD36 is a key transporter involved in fatty acid (FA) uptake and contributes to the accumulation of FA in cardiomyocytes. The objective of this study was to investigate the role of ouabain, a glycoside regulator of Na(+)/K(+)-ATPase, in the regulatio
Autor:
Doaa A. Sourour, Olfat G. Shaker
Publikováno v:
Journal of Cardiovascular Pharmacology. 55:262-268
The present study was designed to compare the cardioprotective effects of the combination of lisinopril with growth hormone over lisinopril alone in doxorubicin (Dox)-induced cardiomyopathy in rats. Forty male Wister albino rats were divided into 4 g
Autor:
Hiromichi Fukushima, Naohiko Kobayashi, Toshihiko Ishimitsu, Hiroshi Takeshima, Wataru Koguchi
Publikováno v:
Journal of Cardiovascular Pharmacology. 55:83-88
Apelin and its cognate G protein-coupled receptor APJ constitute a signaling pathway with a positive inotropic effect on cardiac function, and the apelin/APJ pathway seems to have opposing physiological role to the renin-angiotensin system. We invest
Publikováno v:
Journal of Cardiovascular Pharmacology. 54:16-24
Benazepril, an angiotensin-converting enzyme inhibitor, and candesartan, an angiotensin receptor blocker, are common drugs for treating hypertension. This study aimed to investigate the enhanced attenuation of myocardial fibrosis in spontaneously hyp