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Publikováno v:
Journal of Cardiovascular Pharmacology. 79:335-341
This study aimed to investigate the role of ginsenoside Rh1 in regulating the proliferation, apoptosis, and oxidative stress in oxidized low-density lipoprotein (ox-LDL)-treated human vascular endothelial cells (VECs) and the underlying mechanisms. V
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:809-818
There is evidence that the development of atherosclerosis (AS) involves the dysregulation of circular RNAs. This study aimed to investigate the role of circular ubiquitin-specific peptidase 9 X-linked (circUSP9X) in AS cell models. Human umbilical ve
Autor:
Kim A. Dora, Christopher J Garland
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:S3-S12
Endothelium-derived hyperpolarizing factor (EDHF) was envisaged as a chemical entity causing vasodilation by hyperpolarizing vascular smooth muscle (VSM) cells and distinct from nitric oxide (NO) ([aka endothelium-derived relaxing factor (EDRF)]) and
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:875-884
The accumulation of vascular smooth muscle cells (VSMCs) is considered to play important roles in atherosclerosis (AS) development and progression. Circ_0002984 was found to be increased in oxidized low-density lipoprotein (ox-LDL) human VSMCs (HVSMC
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:e729-e737
Foam cell formation is an important event in atherosclerosis. Fisetin, a bioflavonoid, has been identified to possess anti-inflammatory, antilipidemic, and anticancerous properties; however, its role as a lipid homeostasis regulator in macrophages, s
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:534-543
Excessive proliferation and migration of human vascular smooth muscle cells (HVSMCs) induced by oxidized low-density lipoprotein (ox-LDL) are important pathological features of atherosclerosis. Emerging evidence indicates that circular RNAs deregulat
Autor:
Belay Tesfamariam
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:515-522
Endothelial cells adhere to one another through junctional structures formed by intercellular adhesion molecules. These intercellular proteins regulate barrier function in response to the hemodynamic shear rate and enable the selective passage of sol
Autor:
Luis Cuniberti, Ayelén E. López, Fernanda Daniela Olea, Maria del Rosario Bauza, Paola Locatelli, Alberto J. Crottogini
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:346-360
Adult mammalian cardiomyocytes show scarce division ability, which makes the heart ineffective in replacing lost contractile cells after ischemic cardiomyopathy. In the past decades, there have been increasing efforts in the search for novel strategi
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:235-246
Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be related to atherosclerosis (AS) progression. However, the underlying mechanism of MALAT1 in AS remains unknown. Quantitative real-time polymerase c
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:228-234
Epicardial adipose tissue (EAT) dysfunction mediates chronic inflammation by regulating inflammation-related adipokines and cytokines, and it further promotes coronary artery disease (CAD) development. CD40L/CD40 is involved in multiple inflammatory