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Publikováno v:
Journal of Cardiovascular Pharmacology. 79:335-341
This study aimed to investigate the role of ginsenoside Rh1 in regulating the proliferation, apoptosis, and oxidative stress in oxidized low-density lipoprotein (ox-LDL)-treated human vascular endothelial cells (VECs) and the underlying mechanisms. V
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:809-818
There is evidence that the development of atherosclerosis (AS) involves the dysregulation of circular RNAs. This study aimed to investigate the role of circular ubiquitin-specific peptidase 9 X-linked (circUSP9X) in AS cell models. Human umbilical ve
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:e729-e737
Foam cell formation is an important event in atherosclerosis. Fisetin, a bioflavonoid, has been identified to possess anti-inflammatory, antilipidemic, and anticancerous properties; however, its role as a lipid homeostasis regulator in macrophages, s
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:534-543
Excessive proliferation and migration of human vascular smooth muscle cells (HVSMCs) induced by oxidized low-density lipoprotein (ox-LDL) are important pathological features of atherosclerosis. Emerging evidence indicates that circular RNAs deregulat
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:235-246
Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be related to atherosclerosis (AS) progression. However, the underlying mechanism of MALAT1 in AS remains unknown. Quantitative real-time polymerase c
Publikováno v:
Journal of Cardiovascular Pharmacology. 77:480-490
Atherosclerosis is a chronic lipid-induced inflammation of the vessel wall. Oxidized low-density lipoprotein was confirmed to drive the onset of atherogenesis. Zinc finger e-box-binding homeobox 1 antisense 1 (ZEB1-AS1) is a long noncoding RNA that i
Publikováno v:
Journal of Cardiovascular Pharmacology. 76:617-626
Emerging evidence has demonstrated that long non-coding RNAs (lncRNAs) are related to the pathogenesis of atherosclerosis (AS). We aimed to investigate the roles and molecular mechanisms of myocardial infarction-associated transcript (MIAT) in the pr
Autor:
Ling-Chao Yang, Na Feng, Yong Chen, Fang Liu, Shuang-Xi Zhu, Xiang-Fei Feng, Xue-Juan Yang, Xue-Song Ding
Publikováno v:
Journal of Cardiovascular Pharmacology. 75:45-53
Atherosclerosis is a chronic inflammation condition resulting from the interaction between lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in the arterial wall. Macrophage-derived foam cells play a key role in b
Publikováno v:
Journal of Cardiovascular Pharmacology. 74:53-61
Aim Vascular endothelial cell dysfunction plays a crucial role in the initiation and development of atherosclerosis. Physcion 8-O-β-glucopyranoside (PG), an anthraquinone extracted from Polygonum cuspidatum, has a number of pharmacological functions
Autor:
Yong Liu, Hang Yan, Dan Luo, Yan-Rong Yu, Yan-Qi Fu, Yu-Si Wu, Ming He, Wei-Jie Peng, Qiren Huang
Publikováno v:
Journal of Cardiovascular Pharmacology. 67:519-525
Adhesion of monocytes to the vascular endothelium is crucial in atherosclerosis development. Connexins (Cxs) which form hemichannels or gap junctions, modulate monocyte-endothelium interaction. We previously found that rutaecarpine, an active ingredi