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Publikováno v:
Journal of Cardiovascular Pharmacology. 68:127-142
The development of numerous types of cardiovascular disease is associated with alteration of the vascular smooth muscle cell (SMC) phenotype. We have previously shown that abdominal aortic aneurysm progression in a mouse model of the disease is assoc
Autor:
Yong Liu, Hang Yan, Dan Luo, Yan-Rong Yu, Yan-Qi Fu, Yu-Si Wu, Ming He, Wei-Jie Peng, Qiren Huang
Publikováno v:
Journal of Cardiovascular Pharmacology. 67:519-525
Adhesion of monocytes to the vascular endothelium is crucial in atherosclerosis development. Connexins (Cxs) which form hemichannels or gap junctions, modulate monocyte-endothelium interaction. We previously found that rutaecarpine, an active ingredi
Publikováno v:
Journal of Cardiovascular Pharmacology. 61:176-187
Endothelium-derived hyperpolarizing factors (EDHFs) regulate vascular tone by contributing to the vasorelaxations to shear stress and endothelial agonists such as bradykinin and acetylcholine. 15(S)-Hydroxy-11,12-epoxyeicosatrienoic acid (15-H-11,12-
Publikováno v:
Journal of Cardiovascular Pharmacology. 60:125-132
Autophagy is a housekeeping process which helps to maintain cellular energy homeostasis and remove damaged organelles. In the heart, autophagy is an adaptive process that is activated in response to stress including acute and chronic ischemia. Given
Autor:
José Ramón González-Juanatey, Bruno K. Rodiño-Janeiro, Rafael Ucieda-Somoza, Ezequiel Álvarez
Publikováno v:
Journal of Cardiovascular Pharmacology. 55:203-212
Endothelial dysfunction has been linked to reactive oxygen species (ROS) production by nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase. Angiotensin II (ANG), which levels are elevated in some cardiovascular diseases, can stimulate
Publikováno v:
Journal of Cardiovascular Pharmacology. 50:609-620
Vascular remodeling refers to lasting structural alterations in the vessel wall that are initiated in response to external and internal stimuli. These changes are distinct from acute functional responses of blood vessels when challenged by increased
Publikováno v:
Journal of Cardiovascular Pharmacology. 44:S439-S442
Since endothelin was found to be expressed epithelium as well as vascular enothelium, the functional regulation of various cells with endothelin have been actively investigated. Especially, it is suggested that endothelin may influence pigmentation a
Autor:
Michel Lazdunski
Publikováno v:
Journal of Cardiovascular Pharmacology. 24:S1-S5
ATP-sensitive potassium channels are found in a number of different tissues where they undertake distinct physiologic functions. In endocrine cells they regulate the secretion of hormones such as insulin, prolactin, and growth hormone. They influence
Autor:
Stephen M. Schwartz, Lucy Liaw
Publikováno v:
Journal of Cardiovascular Pharmacology. 21:S31-S49
We briefly review and compare the current knowledge of growth mechanisms for the mitogenic response of endothelial cells and smooth-muscle cells to injury. For the endothelium, this focuses on the evidence that growth control involves two components:
Publikováno v:
ResearcherID
Endothelin-1 (ET-1) mRNA expression and peptide production in human vascular smooth muscle cells (HVSMCs) are markedly increased by exposure to cytokines. As the transcription factor nuclear factor-kappaB (NF-kappaB) often mediates the effects of cyt