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Autor:
Alessandro Cannavo, Walter J. Koch
Publikováno v:
Journal of Cardiovascular Pharmacology
G protein–coupled receptors (GPCRs) are nodal regulators of mammalian cell physiology because they transduce cell signals from diverse ligands such as neurohormones, sensory stimuli, and ions through heterotrimeric G proteins.1 In the heart, they r
Publikováno v:
Journal of Cardiovascular Pharmacology. 62:122-129
The promise of stem cells to repair the heart after damage or heart attack has not been realized because most such cells are lost after transplantation. A new approach is to grow substantial viable pieces of cardiac tissue from human stem cells by ca
Publikováno v:
Journal of Cardiovascular Pharmacology. 60:235-241
Autophagy is an evolutionarily conserved intracellular mechanism for degradation of long-lived proteins and organelles. Accumulating lines of evidence indicate that autophagy is deeply involved in the development of cardiac disease. Autophagy is upre
Publikováno v:
Journal of Cardiovascular Pharmacology. 58:354-362
Directed protein phosphorylation is indisputably critical for a multitude of cellular processes. A growing body of research demonstrates A kinase anchoring proteins (AKAPs) to mediate a significant number of phosphorylation events in the heart. By ac
Autor:
Filomena G. Ottaviano, Karen O Yee
Publikováno v:
Journal of Cardiovascular Pharmacology. 57:513-521
Interspersed between cardiac myocytes, cardiac fibroblasts serve mainly as a structural support during ventricular wall thickening from embryogenesis until adulthood. Cardiac fibroblasts, however, may also serve as a source of mitogens, extracellular
Autor:
Donald M. Bers, Eleonora Grandi
Publikováno v:
Journal of Cardiovascular Pharmacology. 54:180-187
Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase expressed abundantly in the heart. CaMKII targets numerous proteins involved in excitation contraction coupling and excitability and its activation may simul
Publikováno v:
Journal of Cardiovascular Pharmacology. 54:188-195
Nitric oxide (NO) exerts ubiquitous signaling via posttranslational modification of cysteine residues, a reaction termed S-nitrosylation. Important substrates of S-nitrosylation that influence cardiac function include receptors, enzymes, ion channels
Autor:
Roberta A. Gottlieb
Publikováno v:
Journal of Cardiovascular Pharmacology. 53:187-188