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Autor:
Kim A. Dora, Christopher J Garland
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:S3-S12
Endothelium-derived hyperpolarizing factor (EDHF) was envisaged as a chemical entity causing vasodilation by hyperpolarizing vascular smooth muscle (VSM) cells and distinct from nitric oxide (NO) ([aka endothelium-derived relaxing factor (EDRF)]) and
Autor:
Belay Tesfamariam
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:515-522
Endothelial cells adhere to one another through junctional structures formed by intercellular adhesion molecules. These intercellular proteins regulate barrier function in response to the hemodynamic shear rate and enable the selective passage of sol
Autor:
Luis Cuniberti, Ayelén E. López, Fernanda Daniela Olea, Maria del Rosario Bauza, Paola Locatelli, Alberto J. Crottogini
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:346-360
Adult mammalian cardiomyocytes show scarce division ability, which makes the heart ineffective in replacing lost contractile cells after ischemic cardiomyopathy. In the past decades, there have been increasing efforts in the search for novel strategi
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:235-246
Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be related to atherosclerosis (AS) progression. However, the underlying mechanism of MALAT1 in AS remains unknown. Quantitative real-time polymerase c
Autor:
Yibo Li, Dongxu Li, Yaxin Hou, Weizheng Meng, Huibing Liu, Fei Lin, Siyu Sun, Xiulong Wang, Xuefang Li, Guoan Zhao, Kai Wu
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:e30-e39
Mitophagy is involved in the development of various cardiovascular diseases, such as atherosclerosis, heart failure, myocardial ischemia/reperfusion injury, and hypertension. Mitophagy is essential for maintaining intracellular homeostasis and physio
Autor:
Sadia Mohsin, Lindsay Kraus
Publikováno v:
J Cardiovasc Pharmacol
The role of stem cells in augmenting reparative processes in the heart after ischemic injury has been successfully demonstrated in small and large animal models. However, the outcomes of cell therapy in clinical trials have been somewhat variable, wi
Publikováno v:
Journal of Cardiovascular Pharmacology. 75:494-507
The 3',5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase type I (cGKI aka PKGI) is a major cardiac effector acting downstream of nitric oxide (NO)-sensitive soluble guanylyl cyclase and natriuretic peptides (NPs), which signal through
Autor:
Ling-Chao Yang, Na Feng, Yong Chen, Fang Liu, Shuang-Xi Zhu, Xiang-Fei Feng, Xue-Juan Yang, Xue-Song Ding
Publikováno v:
Journal of Cardiovascular Pharmacology. 75:45-53
Atherosclerosis is a chronic inflammation condition resulting from the interaction between lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in the arterial wall. Macrophage-derived foam cells play a key role in b
Autor:
Junichi Sadoshima, Toshihide Kashihara
Publikováno v:
J Cardiovasc Pharmacol
The heart requires a high amount of energy, in the form of adenosine triphosphate, to maintain its viability and pump function. Anaerobic glycolysis and mitochondrial oxidative phosphorylation are the two main metabolic pathways by which adenosine tr
Publikováno v:
Journal of Cardiovascular Pharmacology. 71:193-204
There is significant evidence that internal pools of G protein-coupled receptors (GPCRs) exist and may be affected by both endogenous signaling molecules and hydrophobic pharmaceutical ligands, once assumed to only affect cell surface versions of the