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Autor:
Amanda Pinheiro, Francisco J. Naya
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 84, p 84 (2021)
Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease
Non-coding RNAs (ncRNAs) play a key role in the regulation of transcriptional and epigenetic activity in mammalian cells. Comprehensive analysis of these ncRNAs has revealed sophisticated gene regulatory mechanisms which finely tune the proper gene o
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 87, p 87 (2021)
Journal of Cardiovascular Development and Disease
Volume 8
Issue 8
Pages: 87
Journal of Cardiovascular Development and Disease
Volume 8
Issue 8
Pages: 87
Induction of cardiomyocyte proliferation is a promising option to regenerate the heart. Thus, it is important to elucidate mechanisms that contribute to the cell cycle arrest of mammalian cardiomyocytes. Here, we assessed the contribution of the peri
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 21, p 21 (2021)
Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease
Heart disease remains the single largest cause of death in developed countries, and novel therapeutic interventions are desperately needed to alleviate this growing burden. The cardiac lymphatic system is the long-overlooked counterpart of the corona
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 7, Iss 13, p 13 (2020)
Journal of Cardiovascular Development and Disease
Volume 7
Issue 2
Journal of Cardiovascular Development and Disease
Volume 7
Issue 2
Congenital heart defects (CHDs) occur with such a frequency that they constitute a significant cause of morbidity and mortality in both children and adults. A significant portion of CHDs can be attributed to aberrant development of the cardiac outflo
Autor:
Nicola M Blythe, Neil A. Turner
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 6, Iss 3, p 27 (2019)
Journal of cardiovascular development and disease
Journal of Cardiovascular Development and Disease
Journal of cardiovascular development and disease
Journal of Cardiovascular Development and Disease
The cardiac fibroblast is a remarkably versatile cell type that coordinates inflammatory, fibrotic and hypertrophic responses in the heart through a complex array of intracellular and intercellular signaling mechanisms. One important signaling node t
Autor:
Christine B. Kern
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 92, p 92 (2021)
Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease
A bicuspid aortic valve (BAV) is the most common cardiac malformation, found in 0.5% to 2% of the population. BAVs are present in approximately 50% of patients with severe aortic stenosis and are an independent risk factor for aortic aneurysms. Curre
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 6, Iss 2, p 15 (2019)
Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease
Cardiovascular development is a complex developmental process starting with the formation of an early straight heart tube, followed by a rightward looping and the configuration of atrial and ventricular chambers. The subsequent step allows the separa
Autor:
Jingli Cao, Yingxi Cao
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 6, Iss 1, p 3 (2018)
Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease
The epicardium, a mesothelial layer that envelops vertebrate hearts, has become a therapeutic target in cardiac repair strategies because of its vital role in heart development and cardiac injury response. Epicardial cells serve as a progenitor cell
Autor:
Huseyin C. Yalcin, Huseyin Enes Salman
Publikováno v:
Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease, Vol 8, Iss 14, p 14 (2021)
Journal of Cardiovascular Development and Disease, Vol 8, Iss 14, p 14 (2021)
The heart is the first functional organ in a developing embryo. Cardiac development continues throughout developmental stages while the heart goes through a serious of drastic morphological changes. Previous animal experiments as well as clinical obs
Publikováno v:
Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease, Vol 8, Iss 8, p 8 (2021)
Journal of Cardiovascular Development and Disease, Vol 8, Iss 8, p 8 (2021)
Purpose of review: Both traditional and novel cancer therapies can cause cardiovascular toxicity in patients. In vivo models integrating both cardiovascular and cancer phenotypes allow for the study of on- and off-target mechanisms of toxicity arisin