Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rapp, Ulf R."'
Autor:
Houben, Roland, Becker, Jürgen C, Kappel, Andreas, Terheyden, Patrick, Bröcker, Eva-B, Goetz, Rudolf, Rapp, Ulf R
Publikováno v:
Journal of Carcinogenesis, Vol 3, Iss 1, p 6 (2004)
Journal of Carcinogenesis
Journal of Carcinogenesis
Background Genes of the Raf family encode kinases that are regulated by Ras and mediate cellular responses to growth signals. Recently, it was shown that activating mutations of BRaf are found with high frequency in human melanomas. The Ras family me
Publikováno v:
Journal of Carcinogenesis
Journal of Carcinogenesis, Vol 4, Iss 1, p 23 (2005)
Journal of Carcinogenesis, Vol 4, Iss 1, p 23 (2005)
Background Activation of Ras or Raf contributes to tumorigenesis of melanoma. However, constitutive Raf activation is also a characteristic of the majority of benign melanocytic nevi and high intensity signaling of either Ras or Raf was found to indu