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Autor:
Dinja T. Kruger, Karin Beelen, Vincent van der Noort, Sabine C. Linn, Joyce Sanders, Epie Boven, Mark Opdam, Bart de Valk, Michiel Nieuwenhuis
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Kruger, D T, Opdam, M, van der Noort, V, Sanders, J, Nieuwenhuis, M, de Valk, B, Beelen, K J, Linn, S C & Boven, E 2020, ' PI3K pathway protein analyses in metastatic breast cancer patients receiving standard everolimus and exemestane ', Journal of Cancer Research and Clinical Oncology, vol. 146, no. 11, pp. 3013-3023 . https://doi.org/10.1007/s00432-020-03291-x
Journal of Cancer Research and Clinical Oncology, 146(11), 3013-3023. Springer Verlag
Kruger, D T, Opdam, M, van der Noort, V, Sanders, J, Nieuwenhuis, M, de Valk, B, Beelen, K J, Linn, S C & Boven, E 2020, ' PI3K pathway protein analyses in metastatic breast cancer patients receiving standard everolimus and exemestane ', Journal of Cancer Research and Clinical Oncology, vol. 146, no. 11, pp. 3013-3023 . https://doi.org/10.1007/s00432-020-03291-x
Journal of Cancer Research and Clinical Oncology, 146(11), 3013-3023. Springer Verlag
Purpose Everolimus plus exemestane (EVE/EXE) is a registered treatment option for ER-positive, HER2-negative (ER +/HER2-) metastatic breast cancer (MBC), but resistance mechanisms limit efficacy. We aimed to find markers that might help select patien
Autor:
Boris Duchemann, Jean-Baptiste Assié, Kader Chouahnia, Gaetan Des Guetz, Thierry Landre, Christos Chouaid
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 146:3333-3339
Erlotinib is indicated as first-line treatment for patients with non-small-cell lung cancer (NSCLC) harboring an epidermal growth-factor–receptor (EGFR) mutation. Addition of a vascular endothelial growth factor (VEGF) inhibitor (anti-VEGF) in comb
Autor:
Marcus Vetter, Kerstin Hoeck, Michael Friedlander, Siti Omar, Andreas Schoetzau, Neville F. Hacker, André B. Kind, Viola Heinzelmann-Schwarz, Kenneth J. Russell, Daniel Fink
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Background Malignant mixed Mullerian tumors of endometrial (MMMT-E) and ovarian (MMMT-O) origin are associated with poor prognosis. Suggestively epithelial-driven tumors, their treatment has shifted from anthracycline or ifosfamide-based towards taxa
Autor:
Giorgio Minotti, Pier Luigi Zinzani
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose CD19 is a cell surface protein that is found on both healthy and malignant B cells. Accordingly, it has become an important target for novel treatments for non-Hodgkin lymphomas and B-cell leukaemia. Three anti-CD19 monoclonal antibodies with
Autor:
A. Pryalukhin, Moritz Kohn, Christian Veith, Rainer M. Bohle, Johannes Linxweiler, Kerstin Junker, Markus Hammer, Michael Stöckle, Stefanie Muhs, Matthias Saar
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 145:551-559
To generate and characterize 3D spheroid suspension cultures from radical prostatectomy (RP) specimens as a versatile model system for organ-confined prostate cancer (PCa). Cancerous tissue samples from RP specimens were excised by a uropathologist.
Autor:
Tobias Bartscht, Hartmut Merz, Hendrik Lehnert, Armin Riecke, Hanno M Witte, Dirk Rades, Sebastian Fetscher, Thomas Mayer, Niklas Gebauer, Harald Biersack
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 145:129-136
The introduction of immunochemotherapy has led to a significant improvement in treatment results and prognosis of diffuse large B-cell non-Hodgkins lymphoma (DLBCL) both at initial diagnosis and in relapse. Trofosfamide, an oxazaphosphorine derivativ
Autor:
Mohamed A. Kandeil, Sameera Ezzat, Mohamed O. Mahmoud, Wafaa M. Rashed, Mohamed H. Abdel-Rahman, Doha Maher
Publikováno v:
J Cancer Res Clin Oncol
PURPOSE: Long interspersed nuclear element 1 (LINE-1 or L1) is a dominant non-long terminal repeat (non-LTR) retrotransposon in the human genome that has been implicated in the overexpression of MET. Both the canonical MET and L1-MET transcripts are
Autor:
Paul N. Span, Fred C.G.J. Sweep, Petra L.M. Zusterzeel, Rob van der Steen, Anneke Geurts-Moespot, Karin Abbink
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Journal of Cancer Research and Clinical Oncology, 146, 1725-1735
Journal of Cancer Research and Clinical Oncology, 146, 7, pp. 1725-1735
Journal of Cancer Research and Clinical Oncology, 146, 1725-1735
Journal of Cancer Research and Clinical Oncology, 146, 7, pp. 1725-1735
Objective The plasminogen activator system (PAS) and vascular endothelial growth factor (VEGF) are important in the carcinogenesis and play a key role in cancer invasion and mediating metastasis of carcinomas. The aim of the study was to evaluate the
Autor:
Laurens van Houdt, Niek F H N van Bree, Yvonne M.H. Versleijen-Jonkers, Winette T. A. van der Graaf, Emmy D.G. Fleuren, Janet Shipley, Melissa H.S. Hillebrandt-Roeffen, Thomas Mentzel, Uta Flucke, Ingrid M.E. Desar, Anke E M van Erp
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Journal of Cancer Research and Clinical Oncology, 146, 1659-1670
Journal of Cancer Research and Clinical Oncology, 146, 7, pp. 1659-1670
Journal of Cancer Research and Clinical Oncology, 146, 1659-1670
Journal of Cancer Research and Clinical Oncology, 146, 7, pp. 1659-1670
Purpose Desmoplastic small round cell tumors (DSRCTs) are highly malignant and very rare soft tissue sarcomas with a high unmet need for new therapeutic options. Therefore, we examined poly(ADP-ribose) polymerase 1 (PARP1) and Schlafen-11 (SLFN11) ex
Autor:
Uwe Karsten Hanisch, Peter Vajkoczy, Tobias Kratzsch, Susanne Kuhn, Andreas Joedicke, Iduna Fichtner, Jens Hoffmann
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 144:809-819
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor in adults. The epigenetically active ribonucleoside analog 5-azacitidine is a new therapy option that changes tumor cell chromatin, which is frequently modified by methylation and d