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Autor:
Oumar Camara, Carola Rabenstein, Cornelia Jörke, Klaus Hoeffken, Ingo B. Runnebaum, Katharina Pachmann, Anne Egbe, U. Hammer
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 135(4):643-647
In breast cancers, the gene for the growth factor receptor HER2 can be amplified leading to increased aggressiveness and metastasis formation. The monoclonal antibody trastuzumab prolongs relapse-free survival highly significantly but eventually many
Autor:
Mel Fox, Gary C. Starling, Mian Su, Sonia Tanlimco, Debra Chao, Shiming Ye, Donghee Choi, Johnny Yin, Lisa Durkin, Patricia Culp, Yongke Zhang, Eric D. Hsi, Mien Sho, Han Kim
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Background The receptor for the cytokine TWEAK (TweakR) is a cell surface member of the tumor necrosis factor receptor superfamily with diverse biological roles. TNFRSF family members are appealing therapeutic targets in oncology due to their aberran
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Background and purpose Breast carcinoma is the most common cancer in female patients with a propensity for recurrence and metastases. The accuracy of ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), scintimammography (SMM)
Autor:
Anieta M. Sieuwerts, J. Blom, Agnes Jager, Judith R. Kroep, John W.M. Martens, Caroline Seynaeve, Els M.J.J. Berns, J. Margriet Collée, Ans M.W. van den Ouweland, Mieke Kriege, Marion E. Meijer-van Gelder, Maartje J. Hooning, Antoinette Hollestelle
Publikováno v:
Journal of Cancer Research and Clinical Oncology, 141(10), 1879-1887. Springer-Verlag
Journal of Cancer Research and Clinical Oncology, 141(10), 1879-1887
Journal of Cancer Research and Clinical Oncology
Journal of Cancer Research and Clinical Oncology, 141(10), 1879-1887
Journal of Cancer Research and Clinical Oncology
Purpose The role of CHEK2 in DNA repair by homologous recombination suggests that CHEK2-associated breast cancer (BC) patients might be more sensitive to chemotherapy inducing double-strand DNA breaks, but results hereon are lacking. We compared the
Autor:
Anke Thomas, Sherko Kümmel, Stefan Paepke, Marion Kiechle-Bahat, Ralf Ohlinger, Nadia Harbeck, Mathias Warm, Volker R. Jacobs
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 133(12):905-916
Several large, well-controlled clinical trials have now established that the aromatase inhibitors (AIs), including letrozole, anastrozole, and exemestane, are more effective than tamoxifen when used as adjuvant endocrine therapy in postmenopausal wom