Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tim D. Spector"'
Autor:
Xinyuan Zhang, Adewale S. Adebayo, Dongmeng Wang, Yasrab Raza, Max Tomlinson, Hannah Dooley, Ruth C.E. Bowyer, Kerrin S. Small, Claire J. Steves, Tim D. Spector, Emma L. Duncan, Alessia Visconti, Mario Falchi
Publikováno v:
Journal of Bone and Mineral Research. 38:326-334
Proton pump inhibitors (PPIs) are among the most used drugs in the UK. PPI use has been associated with decreased bone mineral density (BMD) and increased fracture risk, although these results have been inconsistent. We hypothesized that PPI could mo
Autor:
Liesbeth Vandenput, John P. Kemp, Laura M. Yerges-Armstrong, Daniel S. Evans, Braxton D. Mitchell, Charles R. Farber, Scott Wilson, Munro Peacock, Kari Stefansson, Ching-Lung Cheung, Annie Kung, John A Robbins, Tamara B. Harris, Elizabeth A. Streeten, M. Carola Zillikens, Karol Estrada, Kristina Åkesson, Mattias Lorentzon, David Karasik, Gunnar Sigurdsson, Steven R. Cummings, Suzanne J. Brown, Unnur Styrkarsdottir, Candace M. Kammerer, Carolina Medina-Gomez, Thomas J. Beck, Anne B. Newman, Carrie M. Nielson, Kaare M. Gautvik, Cheryl L. Ackert-Bicknell, Fiona E. McGuigan, Douglas P. Kiel, Fernando Rivadeneira, Jonathan H Tobias, Laura D. Carbone, Daniel L. Koller, Sjur Reppe, Katerina Trajanoska, Terence D. Capellini, Tim D. Spector, Michael J. Econs, Evangelos Evangelou, Yi-Hsiang Hsu, Mariel Young, Debbie A Lawlor, Jane A. Cauley, Miryoung Lee, André G. Uitterlinden, Claes Ohlsson, Stefan A. Czerwinski, Serkalem Demissie, J. Brent Richards
Publikováno v:
Hsu, Y H, Estrada, K, Evangelou, E, Ackert-Bicknell, C, Akesson, K, Beck, T, Brown, S J, Capellini, T, Carbone, L, Cauley, J, Cheung, C L, Cummings, S R, Czerwinski, S, Demissie, S, Econs, M, Evans, D, Farber, C, Gautvik, K, Harris, T, Kammerer, C, Kemp, J, Koller, D L, Kung, A, Lawlor, D, Lee, M, Lorentzon, M, McGuigan, F, Medina-Gomez, C, Mitchell, B, Newman, A, Nielson, C, Ohlsson, C, Peacock, M, Reppe, S, Richards, J B, Robbins, J, Sigurdsson, G, Spector, T D, Stefansson, K, Streeten, E, Styrkarsdottir, U, Tobias, J, Trajanoska, K, Uitterlinden, A, Vandenput, L, Wilson, S G, Yerges-Armstrong, L, Young, M, Zillikens, M C, Rivadeneira, F, Kiel, D P & Karasik, D 2019, ' Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry ', Journal of Bone and Mineral Research, vol. 34, no. 7, e3698, pp. 1284-1296 . https://doi.org/10.1002/jbmr.3698
Journal of Bone and Mineral Research, 34(7):UNSP e3698, 1284-1296. Wiley-Blackwell
Journal of Bone and Mineral Research, 34(7):UNSP e3698, 1284-1296. Wiley-Blackwell
Hip geometry (HG) is an important predictor of fracture. We performed a meta-analysis of GWAS studies in adults to identify genetic variants that are associated with proximal femur geometry phenotypes. We analyzed four phenotypes: 1) Femoral neck len
Autor:
Fiona R. Saunders, Scott Wilson, Benjamin H. Mullin, Claudiu V. Giuraniuc, Tim D. Spector, Frederick K. Kamanu, Douglas P. Kiel, Claes Ohlsson, Frances M K Williams, Deborah Jenkins, Denis Baird, Rebecca J. Barr, Nancy E Lane, Benjamin G. Faber, J. Brent Richards, Eric S. Orwoll, Elin Grundberg, Daniel Richard, Lavinia Paternoster, David M. Evans, Thomas J. Beck, Ulrika Pettersson-Kymmer, Jonathan H Tobias, Jennifer S. Gregory, David Karasik, Steven R. Cummings, Daniel S. Evans, Richard M. Aspden, Terence D. Capellini, Debbie A Lawlor
Publikováno v:
Journal of Bone and Mineral Research
Baird, D A, Evans, D S, Kamanu, F K, Gregory, J S, Saunders, F R, Giuraniuc, C V, Barr, R J, Aspden, R M, Jenkins, D, Kiel, D P, Orwoll, E S, Cummings, S R, Lane, N E, Mullin, B H, Williams, F M K, Richards, J B, Wilson, S G, Spector, T D, Faber, B G, Lawlor, D A, Grundberg, E, Ohlsson, C, Pettersson-Kymmer, U, Capellini, T D, Richard, D, Beck, T J, Evans, D M, Paternoster, L, Karasik, D & Tobias, J H 2018, ' Identification of Novel Loci Associated With Hip Shape : A Meta-Analysis of Genomewide Association Studies ', Journal of Bone and Mineral Research . https://doi.org/10.1002/jbmr.3605
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol 34, iss 2
Baird, DA; Evans, DS; Kamanu, FK; Gregory, JS; Saunders, FR; Giuraniuc, CV; et al.(2018). Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies. Journal of Bone and Mineral Research. doi: 10.1002/jbmr.3605. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2tj6x8b6
Baird, D A, Evans, D S, Kamanu, F K, Gregory, J S, Saunders, F R, Giuraniuc, C V, Barr, R J, Aspden, R M, Jenkins, D, Kiel, D P, Orwoll, E S, Cummings, S R, Lane, N E, Mullin, B H, Williams, F M K, Richards, J B, Wilson, S G, Spector, T D, Faber, B G, Lawlor, D A, Grundberg, E, Ohlsson, C, Pettersson-Kymmer, U, Capellini, T D, Richard, D, Beck, T J, Evans, D M, Paternoster, L, Karasik, D & Tobias, J H 2018, ' Identification of Novel Loci Associated With Hip Shape : A Meta-Analysis of Genomewide Association Studies ', Journal of Bone and Mineral Research . https://doi.org/10.1002/jbmr.3605
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol 34, iss 2
Baird, DA; Evans, DS; Kamanu, FK; Gregory, JS; Saunders, FR; Giuraniuc, CV; et al.(2018). Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies. Journal of Bone and Mineral Research. doi: 10.1002/jbmr.3605. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2tj6x8b6
© 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals, Inc. We aimed to report the first genomewide association study (GWAS) meta-analysis of dual-energy X-ray absorptiometry (DXA)-derived hip shape, which is though
Publikováno v:
Journal of Bone and Mineral Research. 31:261-269
Recently, we have begun to realize that the billions of microorganisms living in symbiosis with us have an influence on disease. Evidence is mounting that the alimentary tract microbiome, in particular, influences both host metabolic potential and it
Publikováno v:
Journal of Bone and Mineral Research. 31:326-335
Although a higher protein intake, particularly from vegetable sources, has been shown to be associated with higher bone mineral density (BMD) the relative impact of specific amino acids on BMD and risk of osteoporosis remains to be determined. Mechan
Autor:
Alex J. MacGregor, Ailsa A Welch, Eirini Kelaiditi, Amy Jennings, Tim D. Spector, Claire J. Steves
Publikováno v:
Journal of Bone and Mineral Research. 31:317-325
Age-related loss of skeletal muscle mass and strength are risk factors for sarcopenia, osteoporosis, falls, fractures, frailty, and mortality. Dietary magnesium (Mg) could play a role in prevention of age-related loss of skeletal muscle mass, power,
Autor:
Tomohiro Kuwayama, Michiyo Ohyama, Shinichi Nagase, Tim D. Spector, Steven Boonen, Richard Eastell, Steve Deacon, Maria Small
Publikováno v:
Journal of Bone and Mineral Research. 29:458-466
Cathepsin K inhibitors, such as ONO-5334, are being developed for the treatment of postmenopausal osteoporosis. However, their relative effects on bone resorption and formation, and how quickly the effects resolve after treatment cessation, are uncer
Autor:
Kristina Åkesson, Fiona E. McGuigan, John Blangero, Melanie A. Carless, Ching-Ti Liu, Candace M. Kammerer, François Rousseau, Dongbing Lai, Munro Peacock, Audrey C. Choh, Sylvie Giroux, David Karasik, Tatiana Foroud, Beate St Pourcain, Bradford Towne, David M. Evans, Howard J. Edenberg, Jonathan H Tobias, John P. Kemp, Braxton D. Mitchell, Daniel L. Koller, Debbie A Lawlor, J. Brent Richards, Tim D. Spector, George McMahon, David Goltzman, Laura M. Yerges-Armstrong, Jerilynn C. Prior, Christopher S. Kovacs, Stefan A. Czerwinski, Douglas P. Kiel, Michael J. Econs, Nicholas J. Timpson, Hou-Feng Zheng
Publikováno v:
Journal of Bone and Mineral Research; Vol 28
Previous genome-wide association studies (GWAS) have identified common variants in genes associated with variation in bone mineral density (BMD), although most have been carried out in combined samples of older women and men. Meta-analyses of these r
Publikováno v:
Journal of Bone and Mineral Research. 27:2170-2178
The rate of bone loss varies across the aging period via multiple complex mechanisms. Therefore, the role of genetic factors on bone loss may also change similarly. In this study, we investigated the effect of age on the genetic component of bone los
Autor:
Richard L. Prince, Scott Wilson, Ben H. Mullin, Ian M. Dick, Alessandra C. L. Cervino, Tomi Pastinen, J. Brent Richards, Michelle R. Jones, Katherine S. Elliott, Elin Grundberg, Östen Ljunggren, Tim D. Spector, Frank Dudbridge, Gabriela L. Surdulescu
Publikováno v:
Journal of Bone and Mineral Research. 24:1989-1997
Previous data from our group indicate that BMD is linked to chromosome 3p14-p21. Because the filamin B (FLNB gene resides in this region, is the cause of skeletal dysplasias, and was identified among the top genes in our bioinformatics analysis, we h