Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tatos Akopian"'
Autor:
Alexander Wlodawer, Mi Li, Poorva Dharkar, Alfred L. Goldberg, Olga Kandror, Tatos Akopian, Michael R. Maurizi
Publikováno v:
Journal of Biological Chemistry. 291:7465-7476
The ClpP protease complex and its regulatory ATPases, ClpC1 and ClpX, in Mycobacterium tuberculosis (Mtb) are essential and, therefore, promising drug targets. The Mtb ClpP protease consists of two heptameric rings, one composed of ClpP1 and the othe
Publikováno v:
Journal of Biological Chemistry. 274:3363-3371
Knowledge about the sizes of peptides generated by proteasomes during protein degradation is essential to fully understand their degradative mechanisms and the subsequent steps in protein turnover and generation of major histocompatibility complex cl
Autor:
Abie Craiu, Alfred L. Goldberg, Tatos Akopian, Maria Gaczynska, Kenneth L. Rock, Gabriel Fenteany, Colette F. Gramm
Publikováno v:
Journal of Biological Chemistry. 272:13437-13445
The antibiotic lactacystin was reported to covalently modify beta-subunit X of the mammalian 20 S proteasome and inhibit several of its peptidase activities. However, we demonstrate that [3H]lactacystin treatment modifies all the proteasome's catalyt
Publikováno v:
Journal of Biological Chemistry. 272:1791-1798
Although the structure of the 20 S proteasome from Thermoplasma acidophilum has been elucidated, its enzymatic properties have not been explored in depth. Thermoplasma proteasomes, which contain one type of active site, exhibit not only "chymotrypsin