Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Keith, M."'
Autor:
Epis, Michael R. *, Giles, Keith M. *, Barker, Andrew *, Kendrick, Tulene S. *, Leedman, Peter J. *
Publikováno v:
In Journal of Biological Chemistry 11 September 2009 284(37):24696-24704
Autor:
Jade Bailey, Keith M. Channon, Shoumo Bhattacharya, Helen Batchelor, Surawee Chuaiphichai, Hanneng Zhu, Mark J. Crabtree, Matthew A. Benson, Dennis J. Stuehr
Publikováno v:
Journal of Biological Chemistry. 288:29836-29845
Tetrahydrobiopterin (BH4) is a required cofactor for the synthesis of NO by NOS. Bioavailability of BH4 is a critical factor in regulating the balance between NO and superoxide production by endothelial NOS (eNOS coupling). Crystal structures of the
Publikováno v:
The Journal of Biological Chemistry
Europe PubMed Central
Europe PubMed Central
Background: Both tetrahydrobiopterin (BH4) and S-glutathionylation are important regulators of eNOS activity and coupling. Results: S-Glutathionylation and BH4 deficiency induce eNOS uncoupling through distinct mechanisms but are mutually regulated b
Autor:
Andrew Barker, Keith M. Giles, Felicity C. Kalinowski, Peter J. Leedman, Michael R. Epis, Ronald J. Cohen
Publikováno v:
Journal of Biological Chemistry. 287:35251-35259
The enzyme deoxyhypusine hydroxylase (DOHH) catalyzes the activation of eukaryotic translation initiation factor (eIF5A), a protein essential for cell growth. Using bioinformatic predictions and reporter gene assays, we have identified a 182-nt eleme
Autor:
John Spencer Evans, Keith M. Bromley, Daming Fan, Rajamani Lakshminarayanan, Sowmya Bekshe Lokappa, Andrew Kiss, Janet Moradian-Oldak, Moise Ndao
Publikováno v:
Journal of Biological Chemistry. 286:34643-34653
Amelogenin self-assembles to form an extracellular protein matrix, which serves as a template for the continuously growing enamel apatite crystals. To gain further insight into the molecular mechanism of amelogenin nanosphere formation, we manipulate
Autor:
Malcolm L. Snead, Rajamani Lakshminarayanan, Keith M. Bromley, Yaping Lei, Janet Moradian-Oldak
Publikováno v:
Journal of Biological Chemistry. 285:40593-40603
Mutations in amelogenin sequence result in defective enamel, and the diverse group of genetically altered conditions is collectively known as amelogenesis imperfecta (AI). Despite numerous studies, the detailed molecular mechanism of defective enamel
Publikováno v:
Journal of Biological Chemistry. 284:28128-28136
Tetrahyrobiopterin (BH4) is a required cofactor for the synthesis of nitric oxide by endothelial nitric-oxide synthase (eNOS), and BH4 bioavailability within the endothelium is a critical factor in regulating the balance between NO and superoxide pro
Autor:
Keith M. Channon, Shijie Cai, Mark J. Crabtree, Nicholas Warrick, Amy L. Tatham, Yasir Al-Wakeel, Ashley B. Hale, Nicholas J. Alp
Publikováno v:
Journal of Biological Chemistry. 284:1136-1144
Tetrahydrobiopterin (BH4) is a critical determinant of endothelial nitric-oxide synthase (eNOS) activity. In the absence of BH4, eNOS becomes "uncoupled" and generates superoxide rather than NO. However, the stoichiometry of intracellular BH4/eNOS in
Autor:
Mary Elizabeth Harben, Alec E. Hodel, Kanika F. Pulliam, Keith M. Berland, Mary R. Hodel, Jordan S. Holmes, Michelle T. Harreman, Anita H. Corbett
Publikováno v:
Journal of Biological Chemistry. 281:23545-23556
Nuclear localization signals (NLSs) target proteins into the nucleus through mediating interactions with nuclear import receptors. Here, we perform a quantitative analysis of the correlation between NLS receptor affinity and the steady-state distribu
Publikováno v:
Journal of Biological Chemistry. 279:34505-34513
The neuronal glutamate transporter, EAAC1, appears to both limit spillover between excitatory synapses and provide precursor for the synthesis of the inhibitory neurotransmitter, γ-aminobutyric acid. There is evidence for a large intracellular pool