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pro vyhledávání: '"John McLauchlan"'
Autor:
John McLauchlan, Qifeng Zhang, Charlotte V. Hague, Michael J.O. Wakelam, Jolanda M. P. Liefhebber
Publikováno v:
The Journal of Biological Chemistry
Background: Lipid droplets have been implicated in HCV virion assembly. Results: Inhibitors of the synthesis of triacylglycerol and cholesterol ester, the main components of lipid droplets, impair virion assembly. Conclusion: Production of infectious
Autor:
François Helle, Ursula Andréo, Marine Walic, Jean-Pierre Lavergne, Patrick Maillard, Agata Budkowska, Adeline Mallet, Steeve Boulant, Lucie Goueslain, Farzin Roohvand, John McLauchlan
Publikováno v:
Journal of Biological Chemistry
Early events leading to the establishment of hepatitis C virus (HCV) infection are not completely understood. We show that intact and dynamic microtubules play a key role in the initiation of productive HCV infection. Microtubules were required for v
Autor:
R. Graham Hope, John McLauchlan, Roland Montserret, Jean-Pierre Lavergne, Francoise Penin, Steeve Boulant, Maxime Ratinier, Paul Targett-Adams
Publikováno v:
Journal of Biological Chemistry. 281:22236-22247
Hepatitis C virus core protein is targeted to lipid droplets, which serve as intracellular storage organelles, by its C-terminal domain, termed D2. From circular dichroism and nuclear magnetic resonance analyses, we demonstrate that the major structu