Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Philip Hinchliffe, Karina Calvopiña, Patrick Rabe, Maria F. Mojica, Christopher J. Schofield, Gary I. Dmitrienko, Robert A. Bonomo, Alejandro J. Vila, James Spencer
Publikováno v:
Journal of Biological Chemistry. 299:104606
Autor:
Xiao Liu, Raphael Reinbold, Shuang Liu, Ryan A. Herold, Patrick Rabe, Stéphanie Duclos, Rahul B. Yadav, Martine I. Abboud, Sandrine Thieffine, Fraser A. Armstrong, Lennart Brewitz, Christopher J. Schofield
Publikováno v:
Journal of Biological Chemistry. 299:102873
Variants of isocitrate dehydrogenase (IDH) 1 and 2 (IDH1/2) alter metabolism in cancer cells by catalyzing the NADPH-dependent reduction of 2-oxoglutate (2OG) to (2R)-hydroxyglutarate (2HG). However, it is unclear how derivatives of 2OG can affect ca
Autor:
James Wickens, Adam P. Hardy, Anthony Tumber, Martine I. Abboud, Michael A. McDonough, Christopher T. Lohans, Rasheduzzaman Chowdhury, Christopher M. West, Kerstin Lippl, Christopher J. Schofield, Elisabete Pires, Tongri Liu
Publikováno v:
The Journal of Biological Chemistry
In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate the levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist in other types of eukaryotes and prokaryotes where they act on n
Autor:
Emily Flashman, Holger B. Kramer, Nikita D. Loik, Christopher J. Schofield, Emily A. Howe, Hanna Tarhonskaya, James S. O. McCullagh, Adam P. Hardy
Publikováno v:
The Journal of Biological Chemistry
Background: The hypoxia-inducible factor (HIF) hydroxylases (FIH and PHDs) regulate hypoxia sensing in animals. Results: FIH·HIF-α reacts faster with O2 than PHD2·HIF-α but slower than FIH·ankyrin complexes. Conclusion: The kinetics of catalysis
Autor:
M. Vollmar, Sarah K. Madden, Catrine Johansson, Carina Gileadi, Louise J. Walport, Christopher J. Schofield, Udo Oppermann, Richard J. Hopkinson
Publikováno v:
The Journal of Biological Chemistry
Background: UTY(KDM6C) has been reported previously to be inactive as a histone demethylase. Results: Crystallography reveals that the fold of the UTY(KDM6C) catalytic domain is highly conserved with those of KDM6A/B. UTY(KDM6C) catalyzes demethylati
Autor:
Charles K. Allerston, Peter J. McHugh, John A. Hartley, Sook Y. Lee, Konstantinos Kiakos, Janet M. Hartley, Blanka Sengerová, Mika Abu, Christopher J. Schofield, Opher Gileadi
Publikováno v:
The Journal of Biological Chemistry
Background: The nucleases hSNM1A and hSNM1B are implicated in DNA interstrand cross-link repair. Results: hSNM1A and hSNM1B were biochemically characterized using undamaged and cross-linked DNA. A real-time assay for the nucleases suitable for inhibi
Autor:
Ya-Min Tian, Holger B. Kramer, Kar Kheng Yeoh, Carsten Willam, Peter J. Ratcliffe, Christopher W. Pugh, Mariola J. Edelmann, Myung Kyu Lee, Benedikt M. Kessler, Tuula Eriksson, Christopher J. Schofield
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
Hypoxia inducible factor (HIF) is regulated by dual pathways involving oxygen-dependent prolyl and asparaginyl hydroxylation of its α-subunits. Prolyl hydroxylation at two sites within a central degradation domain promotes association of HIF-α with
Autor:
Michael A. McDonough, Holger B. Kramer, Timothy D. W. Claridge, Ming Yang, Wei Ge, Rasheduzzaman Chowdhury, Christopher J. Schofield, Bernhard Schmierer, Mathew L. Coleman, Peter J. Ratcliffe, Benedikt M. Kessler, Lingzhi Gong
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Factor-inhibiting hypoxia-inducible factor (FIH) catalyzes the β-hydroxylation of an asparagine residue in the C-terminal transcriptional activation domain of the hypoxia inducible factor (HIF), a modification that negatively regulates HIF transcrip
Autor:
Kristina M. Cook, Christopher J. Schofield, Jasmin Mecinović, William B. Motherwell, Stephen T. Hilton, William D. Figg
Publikováno v:
Journal of Biological Chemistry. 284:26831-26838
The hypoxic response in humans is regulated by the hypoxia-inducible transcription factor system; inhibition of hypoxia-inducible factor (HIF) activity has potential for the treatment of cancer. Chetomin, a member of the epidithiodiketopiperazine (ET
Autor:
Christopher J. Schofield, Michael A. McDonough, Luke A. McNeill, Alexei S. Soares, Neil J. Oldham, Ian J. Clifton, Kirsty S. Hewitson, Danica Butler, Benoît M. R. Liénard
Publikováno v:
Journal of Biological Chemistry. 282:3293-3301
In humans both the levels and activity of the alpha-subunit of the hypoxia-inducible transcription factor (HIF-alpha) are regulated by its post-translation hydroxylation as catalyzed by iron- and 2-oxoglutarate (2OG)-dependent prolyl and asparaginyl