Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Aaron N. Hata"'
Publikováno v:
Journal of Biological Chemistry. 280:32442-32451
The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a G protein-coupled receptor that mediates the pro-inflammatory effects of prostaglandin D(2) (PGD(2)) generated in allergic inflammation. The CRTH2 receptor shares gr
Autor:
Richard M. Breyer, Jason D. Morrow, Ines Macias-Perez, Shouzuo Wei, Aaron N. Hata, J. Capdevila, Xuexian Yan, Ambra Pozzi
Publikováno v:
Journal of Biological Chemistry. 279:29797-29804
Cyclooxygenase (COX) and its prostanoid metabolites have been implicated in the control of cell survival; however, their role as mitogens remains undefined. To better understand the role of prostanoids on cell growth, we used mouse colon adenocarcino
Autor:
Mitsuru Emi, Ituro Inoue, Z Shuhua, Aaron N. Hata, Dana E. Wilson, D N Ridinger, T Cheng, S.D. Sutherland, K Ren, R L Myers
Publikováno v:
Journal of Biological Chemistry. 268:8447-8457
Binding to heparan sulfate governs many aspects of the physiological action and regulation of the lipolytic enzyme, lipoprotein lipase (LPL). In an attempt to identify the structural determinants which mediate this interaction, basic residues in thre
Autor:
D N Ridinger, Mitsuru Emi, A Lubbers, Aaron N. Hata, B Guy-Grand, J Shuhua, A Basdevant, P H Iverius, S.D. Sutherland, L.K. Kwong
Publikováno v:
Journal of Biological Chemistry. 267:20132-20139
Most missense mutations of the lipoprotein lipase (LPL) gene identified among LPL-deficient subjects cluster in a segment of the sequence that encodes the catalytic triad as well as functional elements involved in the activation of the lipase at lipi
Autor:
Aaron N. Hata, Mitsuru Emi, Dana E. Wilson, Robert M. Hegele, Long Jun Wu, Roger R. Williams, Jean-Marc Lalouel, P H Iverius
Publikováno v:
Journal of Biological Chemistry. 265:5910-5916
Cloning and sequencing of lipoprotein lipase (LPL) cDNA prepared from the adipose tissue of a patient with classical LPL deficiency revealed a G to A transition at nucleotide 818 in all sequenced clones, leading to the substitution of glutamic acid f