Zobrazeno 1 - 10
of 144
pro vyhledávání: '"A. Pak"'
Autor:
Chen, Xingxiang, Arciola, Jeffrey M., Lee, Young il, Wong, Pak Hung Philip, Yin, Haoran, Tao, Quanqing, Jin, Yuqi, Qin, Xianan, Sweeney, H Lee, Park, Hyokeun
Publikováno v:
In Journal of Biological Chemistry January 2024 300(1)
Autor:
Kong, Wai-Po, Gong, Furong, So, Pui-Kin, Chen, Yu Wai, Chan, Pak-Ho, Leung, Yun-Chung, Wong, Kwok-Yin
Publikováno v:
In Journal of Biological Chemistry August 2022 298(8)
Autor:
Wai-Po Kong, Furong Gong, Pui-Kin So, Yu Wai Chen, Pak-Ho Chan, Yun-Chung Leung, Kwok-Yin Wong
Publikováno v:
Journal of Biological Chemistry. 298:102235
FtsQBL is a transmembrane protein complex in the divisome of Escherichia coli that plays a critical role in regulating cell division. Although extensive efforts have been made to investigate the interactions between the three involved proteins, FtsQ,
Autor:
Peiman Hematti, Chelsea Hope, Shigeki Miyamoto, Fotis Asimakopoulos, Shelly M. Wuerzberger-Davis, Natalie S. Callander, Lixin Rui, Chorom Pak, John A. Kink, Stephanie Markovina, Mailee Huynh, Debayan D. Bakshi, Kenneth S. Chng
Publikováno v:
Journal of Biological Chemistry. 293:2452-2465
Nuclear factor-κB (NF-κB) is a family of transcription factors that play a key role in cell survival and proliferation in many hematological malignancies, including multiple myeloma (MM). Bortezomib, a proteasome inhibitor used in the management of
Autor:
Nicholas V G Iannantuono, Ian Hammond-Martel, Salima Daou, Michele Carbone, Eric Milot, Frédérick A. Mallette, Helen Pak, El Bachir Affar, Jessica Gagnon, Hugo Wurtele, Alena Motorina, Helen Yu, Nadine Sen Nkwe, Nazar Mashtalir, Haithem Barbour
Publikováno v:
Journal of Biological Chemistry. 290:28643-28663
The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes ubiquitin removal from histone H2A Lys-119 and coordinates cell proliferation, but how BAP1 partners modulate its function remains poorly understood. Here, we report that BAP1 forms two mut
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Autor:
Stephen C. Pak, James C. Whisstock, Gary A. Silverman, Cliff J. Luke, Phillip I. Bird, James A. Huntington, Stephen P. Bottomley, Jean-Marc Reichhart, Dion Kaiserman
Publikováno v:
Journal of Biological Chemistry. 285:24299-24305
Inhibitory serpins are metastable proteins that undergo a substantial conformational rearrangement to covalently trap target peptidases. The serpin reactive center loop contributes a majority of the interactions that serpins make during the initial b
Publikováno v:
Journal of Biological Chemistry. 284:11100-11109
Ca2+ modulates the visual response in both vertebrates and invertebrates. In Drosophila photoreceptors, an increase of cytoplasmic Ca2+ mimics light adaptation. Little is known regarding the mechanism, however. We explored the role of the sole Drosop
Metalloproteinase- and γ-Secretase-mediated Cleavage of Protein-tyrosine Phosphatase Receptor Type Z
Publikováno v:
Journal of Biological Chemistry. 283:30879-30889
Protein-tyrosine phosphatase receptor type Z (Ptprz) is preferentially expressed in the brain as a major chondroitin sulfate proteoglycan. Three splicing variants, two receptor isoforms and one secretory isoform, are known. Here, we show that the ext
Autor:
Merja Jaronen, Jari Koistinaho, Egils Arens, Pak H. Chan, Karl E.O. Åkerman, Velta Keksa-Goldsteine, Toni Ahtoniemi, Gundars Goldsteins
Publikováno v:
Journal of Biological Chemistry. 283:8446-8452
This work demonstrates how increased activity of copper-zinc superoxide dismutase (SOD1) paradoxically boosts production of toxic reactive oxygen species (ROS) in the intermembrane space (IMS) of mitochondria. Even though SOD1 is a cytosolic enzyme,