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pro vyhledávání: '"Christopher J. Schofield"'
Autor:
James Wickens, Adam P. Hardy, Anthony Tumber, Martine I. Abboud, Michael A. McDonough, Christopher T. Lohans, Rasheduzzaman Chowdhury, Christopher M. West, Kerstin Lippl, Christopher J. Schofield, Elisabete Pires, Tongri Liu
Publikováno v:
The Journal of Biological Chemistry
In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate the levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist in other types of eukaryotes and prokaryotes where they act on n
Autor:
Kristina M. Cook, Christopher J. Schofield, Jasmin Mecinović, William B. Motherwell, Stephen T. Hilton, William D. Figg
Publikováno v:
Journal of Biological Chemistry. 284:26831-26838
The hypoxic response in humans is regulated by the hypoxia-inducible transcription factor system; inhibition of hypoxia-inducible factor (HIF) activity has potential for the treatment of cancer. Chetomin, a member of the epidithiodiketopiperazine (ET
Autor:
Christopher J. Schofield, Michael A. McDonough, Luke A. McNeill, Alexei S. Soares, Neil J. Oldham, Ian J. Clifton, Kirsty S. Hewitson, Danica Butler, Benoît M. R. Liénard
Publikováno v:
Journal of Biological Chemistry. 282:3293-3301
In humans both the levels and activity of the alpha-subunit of the hypoxia-inducible transcription factor (HIF-alpha) are regulated by its post-translation hydroxylation as catalyzed by iron- and 2-oxoglutarate (2OG)-dependent prolyl and asparaginyl