Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
James Wickens, Adam P. Hardy, Anthony Tumber, Martine I. Abboud, Michael A. McDonough, Christopher T. Lohans, Rasheduzzaman Chowdhury, Christopher M. West, Kerstin Lippl, Christopher J. Schofield, Elisabete Pires, Tongri Liu
Publikováno v:
The Journal of Biological Chemistry
In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate the levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist in other types of eukaryotes and prokaryotes where they act on n
Autor:
Charles K. Allerston, Peter J. McHugh, John A. Hartley, Sook Y. Lee, Konstantinos Kiakos, Janet M. Hartley, Blanka Sengerová, Mika Abu, Christopher J. Schofield, Opher Gileadi
Publikováno v:
The Journal of Biological Chemistry
Background: The nucleases hSNM1A and hSNM1B are implicated in DNA interstrand cross-link repair. Results: hSNM1A and hSNM1B were biochemically characterized using undamaged and cross-linked DNA. A real-time assay for the nucleases suitable for inhibi
Publikováno v:
Journal of Biological Chemistry. 281:24024-24035
Although the subject of many studies, detailed structural information on aspects of the catalytic cycle of serine proteases is lacking. Crystallographic analyses were performed in which an acyl-enzyme complex, formed from elastase and a peptide, was
Autor:
Charles M. H. Hensgens, Sarah J. Lipscomb, Jack E. Baldwin, Kirsty S. Hewitson, Matthew D. Lloyd, Christopher J. Schofield
Publikováno v:
Journal of Biological Chemistry. 279:15420-15426
Deacetoxycephalosporin/deacetylcephalosporin C synthase (DAOC/DACS) is an iron(II) and 2-oxoglutarate-dependent oxygenase involved in the biosynthesis of cephalosporin C in Cephalosporium acremonium. It catalyzes two oxidative reactions, oxidative ri
Autor:
Linh X. Doan, Hikokazu Suzuki, Rupert C. Wilmouth, Ian J. Clifton, Christopher J. Schofield, Maya Topf, Mark C. Sleeman
Publikováno v:
Journal of Biological Chemistry. 278:20843-20850
The proposed biosynthetic pathway to the carbapenem antibiotics proceeds via epimerization/desaturation of a carbapenam in an unusual process catalyzed by an iron- and 2-oxoglutarate-dependent oxygenase, CarC. Crystal structures of CarC complexed wit