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Autor:
Karim Bouzakri, Katharina Rickenbach, Caroline Arous, Michel Pinget, Bernhard Wehrle-Haller, Maria L. Mizgier
Publikováno v:
Journal of Biological Chemistry, Vol. 295, No 49 (2020) pp. 16510-16528
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Elevated levels of fasting insulin release and insufficient glucose-stimulated insulin secretion (GSIS) are hallmarks of diabetes. Studies have established cross-talk between integrin signaling and insulin activity, but more details of how integrin-d
Autor:
Elliot A. Philips, Benjamin G. Neel, Beatrix Ueberheide, Kieran Adam, Anna S. Tocheva, Marianne Strazza, Adam Mor, Inbar Azoulay-Alfaguter, Shalom Lerrer, Connor Foster, Michael Peled, Shruti Nayak
Publikováno v:
The Journal of Biological Chemistry
Programmed cell death protein 1 (PD-1) is a critical inhibitory receptor that limits excessive T cell responses. Cancer cells have evolved to evade these immunoregulatory mechanisms by upregulating PD-1 ligands and preventing T cell–mediated anti-t
Autor:
Dandan Wang, Ke Gong, Jihong Han, Xiaoxiao Yang, Huaqing Hu, Yongyao Gao, Yajun Duan, Yuanli Chen, Yu Maoyun, Ximei Wu, Chenzhong Liao
Publikováno v:
J Biol Chem
Ascorbic acid, a water-soluble antioxidant, regulates various biological processes and is thought to influence cholesterol. However, little is known about the mechanisms underpinning ascorbic acid-mediated cholesterol metabolism. Here, we determined
Autor:
Susan A. Farr, Su Gao, Clemence Girardet, Jinsong Zhang, Subhashis Banerjee, Jose E. Galgani, Mauricio Castro-Sepulveda, Maria L. Mizgier, Kyle S. McCommis, Michael L. Niehoff, Andrew A. Butler, Joseph R. Stevens, Sarbani Ghoshal, K. Ganesh Kumar
Publikováno v:
J Biol Chem
The micropeptide adropin encoded by the clock-controlled energy homeostasis–associated gene is implicated in the regulation of glucose metabolism. However, its links to rhythms of nutrient intake, energy balance, and metabolic control remain poorly
Autor:
Kumi Suzuki, Peter J. Meikle, Alexis Díaz-Vegas, Gregory J. Cooney, Bianca Varney, Kristen C. Cooke, Akiyoshi Hirayama, Fiona Weiss, James R. Krycer, Deanne Francis, Marin E. Nelson, Richard Scalzo, Lake-Ee Quek, Sean J. Humphrey, Tomoyoshi Soga, Futaba Shoji, Shilpa R. Nagarajan, Corey Giles, Satsuki Ikeda, Andrew J. Hoy, Kevin Huynh, Daniel J. Fazakerley, Armella Zadoorian, David E. James
Publikováno v:
J Biol Chem
Adipose tissue is essential for metabolic homeostasis, balancing lipid storage and mobilization based on nutritional status. This is coordinated by insulin, which triggers kinase signaling cascades to modulate numerous metabolic proteins, leading to
Autor:
Keitaro Yamanouchi, Shiro Minami, Katsuyuki Nakamura, Hidetoshi Sugihara, Reiko Tokita, Hisanori Kato, Yuka Toyoshima, Naomi Teramoto
Publikováno v:
J Biol Chem
Insulin receptor substrate (IRS)-2, along with IRS-1, is a key signaling molecule that mediates the action of insulin and insulin-like growth factor (IGF)-I. The activated insulin and IGF-I receptors phosphorylate IRSs on tyrosine residues, leading t
Autor:
Thorsten Stiewe, Linda Bittel, Marco Mernberger, Stephan Pleschka, Eva Böttcher-Friebertshäuser, Klaus Schughart, Torsten Steinmetzer, Anne Harbig, Andrea Nist
Publikováno v:
J Biol Chem
The Journal of biological chemistry
United States
The Journal of biological chemistry
United States
Cleavage of influenza virus hemagglutinin (HA) by host proteases is essential for virus infectivity. HA of most influenza A and B (IAV/IBV) viruses is cleaved at a monobasic motif by trypsin-like proteases. Previous studies have reported that transme
Autor:
Haruhiko Kamada, Yasuo Tsutsumi, Kanako Yamashita, Natsuki Osaki, Masaki Inoue, Masahiro Kunishige, Shota Amano, Yuki Morita, Yuta Tsuji, Shota Enomoto, Chinatsu Yoshimine, Shin-ichi Tsunoda, Midori Miki
Publikováno v:
J Biol Chem
Excessive activation of the proinflammatory cytokine tumor necrosis factor-α (TNFα) is a major cause of autoimmune diseases, including rheumatoid arthritis. TNFα induces immune responses via TNF receptor 1 (TNFR1) and TNFR2. Signaling via TNFR1 in
Publikováno v:
Journal of Biological Chemistry. 295:9455-9473
The human pathogen Mycobacterium tuberculosis (Mtb) harbors a well-orchestrated Clp (caseinolytic protease) proteolytic machinery consisting of two oligomeric segments, a barrel-shaped heterotetradecameric protease core comprising the ClpP1 and ClpP2
Autor:
Yingjie Li, Hong Zhou, Ang Ma, Xiaoqiang Geng, Jinzhao He, Guangping Chen, Min Li, Shun Zhang, Baoxue Yang
Publikováno v:
J Biol Chem
Urea transporters are a family of urea-selective channel proteins expressed in multiple tissues that play an important role in the urine-concentrating mechanism of the mammalian kidney. Previous studies have shown that knockout of urea transporter (U