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Autor:
Karim Bouzakri, Katharina Rickenbach, Caroline Arous, Michel Pinget, Bernhard Wehrle-Haller, Maria L. Mizgier
Publikováno v:
Journal of Biological Chemistry, Vol. 295, No 49 (2020) pp. 16510-16528
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Elevated levels of fasting insulin release and insufficient glucose-stimulated insulin secretion (GSIS) are hallmarks of diabetes. Studies have established cross-talk between integrin signaling and insulin activity, but more details of how integrin-d
Autor:
Keitaro Yamanouchi, Shiro Minami, Katsuyuki Nakamura, Hidetoshi Sugihara, Reiko Tokita, Hisanori Kato, Yuka Toyoshima, Naomi Teramoto
Publikováno v:
J Biol Chem
Insulin receptor substrate (IRS)-2, along with IRS-1, is a key signaling molecule that mediates the action of insulin and insulin-like growth factor (IGF)-I. The activated insulin and IGF-I receptors phosphorylate IRSs on tyrosine residues, leading t
Autor:
Daniel J. Fazakerley, Alexis Díaz-Vegas, Sarah D. Elkington, Gregory J. Cooney, David E. James, Kelsey H. Fisher-Wellman, James G. Burchfield, James R. Krycer, Kristen C. Cooke
Publikováno v:
J Biol Chem
Insulin action in adipose tissue is crucial for whole-body glucose homeostasis, with insulin resistance being a major risk factor for metabolic diseases such as type 2 diabetes. Recent studies have proposed mitochondrial oxidants as a unifying driver
Autor:
Zhuo Xian Meng, Xingjiang Mu, Jiangtong Peng, Yutian Li, Tianqing Peng, Xiaohong Wang, Shan Deng, Guo-Chang Fan, Kobina Essandoh
Publikováno v:
J Biol Chem
The initiation and development of diabetes are mainly ascribed to the loss of functional β-cells. Therapies designed to regenerate β-cells provide great potential for controlling glucose levels and thereby preventing the devastating complications a
Autor:
Katarzyna A. Broniowska, Jennifer S. Stancill, Aaron Naatz, Bryndon J. Oleson, John A. Corbett
Publikováno v:
Journal of Biological Chemistry. 294:4843-4853
Oxidative stress is thought to promote pancreatic β-cell dysfunction and contribute to both type 1 and type 2 diabetes. Reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, are mediators of oxidative stress that arise largely fro
Autor:
Else Marie Valbjørn Hagelin, Jianhua Wang, Ashish K. Gadicherla, Ole Jørgen Kaasbøll, Vivi Talstad Monsen, Håvard Attramadal, Meng-Qiu Dong
Publikováno v:
Journal of Biological Chemistry. 293:17953-17970
Connective tissue growth factor (CTGF; now often referred to as CCN2) is a secreted protein predominantly expressed during development, in various pathological conditions that involve enhanced fibrogenesis and tissue fibrosis, and in several cancers
Publikováno v:
Journal of Biological Chemistry. 293:13112-13124
Fine-tuning of the activity of inositol 1,4,5-trisphosphate receptors (IP(3)R) by a diverse array of regulatory inputs results in intracellular Ca(2+) signals with distinct characteristics. These events allow the activation of specific downstream eff
Publikováno v:
Journal of Biological Chemistry. 293:8578-8587
Tankyrase 1 and 2, members of the poly(ADP-ribose) polymerase family, have previously been shown to play a role in insulin-mediated glucose uptake in adipocytes. However, their precise mechanism of action, and their role in insulin action in other ce
Autor:
D. Fernando Estrada
Publikováno v:
Journal of Biological Chemistry. 293:4167-4179
Mitochondrial cytochromes P450 (P450s) are responsible for important metabolic reactions, including steps involved in steroid and vitamin D metabolism. The mitochondrial P450 24A1 (CYP24A1) is responsible for deactivation of the bioactive form of vit
Autor:
Runping Fang, Xiaodong Zhang, Hui Shi, Hang Li, Zhen Wang, Lihong Ye, Yinghui Li, Weiying Zhang, Huawei Wang
Publikováno v:
Journal of Biological Chemistry. 293:2053-2065
The activation of insulin gene transcription depends on multiple nuclear proteins, including the transcription factors PDX-1 and NEUROD1, which form a transcriptional complex. We recently reported that hepatitis B X-interacting protein (HBXIP, also t