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Publikováno v:
Journal of Biological Chemistry. 283:6546-6560
Attempts to promote neuronal survival and repair with ciliary neurotrophic factor (CNTF) have met with limited success. The variability of results obtained with CNTF may, in part, reflect the fact that some of the biological actions of the cytokine a
Publikováno v:
Journal of Biological Chemistry. 283:2478-2487
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a membrane-bound, Kunitz-type serine protease inhibitor. HAI-1 inhibits serine proteases that have potent pro-hepatocyte growth factor-converting activity, such as the membrane-type serin
Autor:
Lisbeth Gauguin, Briony E. Forbes, Birgit Klaproth, Kerrie A. McNeil, Asser Sloth Andersen, Waseem Sajid, Pierre De Meyts
Publikováno v:
Journal of Biological Chemistry. 283:2604-2613
Insulin and the insulin-like growth factors (IGFs) bind with high affinity to their cognate receptor and with lower affinity to the noncognate receptor. The major structural difference between insulin and the IGFs is that the IGFs are single chain po
Autor:
Rachael M. Clarke, Claire E. Barry, Brian F. Deighan, Florence O’Connell, NG Anyakoha, Anthony Lyons, Anna Nicolaou, Marina A. Lynch
Publikováno v:
Journal of Biological Chemistry. 283:1808-1817
Inflammatory changes, characterized by an increase in pro-inflammatory cytokine production and up-regulation of the corresponding signaling pathways, have been described in the brains of aged rats and rats treated with the potent immune modulatory mo
Autor:
Patrick P. McDonald, Martine Charbonneau, Kelly Harper, Claire M. Dubois, Francine Grondin, Manuela Pelmus
Publikováno v:
Journal of Biological Chemistry. 282:33714-33724
Chronic hypoxia and inflammatory cytokines are hallmarks of inflammatory joint diseases like rheumatoid arthritis (RA), suggesting a link between this microenvironment and central pathological events. Because TACE/ADAM17 is the predominant protease c
Publikováno v:
Journal of Biological Chemistry. 282:35179-35186
Recently, single chain peptides have been designed that target the insulin receptor and mimic insulin action. The aim of this study is to explore if activation of the insulin receptor with such an optimized peptide (S597) leads to the same activation
Autor:
Dirk A. Bornemeier, Alexander Pavlovsky, Hyo-Kyung Han, Adam R. Johnson, Roberto N. De Guzman, Craig Banotai, Faith Prior, W. Howard Roark, Kaushik Datta, Patrick I. McConnell, Charles Lesch, W. Thomas Mueller, Richard D. Dyer, Chunhong Yan, Vijay Baragi, Daniel F. Ortwine, Michael D. Wilson, Chiu-Fai Man
Publikováno v:
Journal of Biological Chemistry. 282:27781-27791
Matrix metalloproteinase-13 (MMP13) is a Zn(2+)-dependent protease that catalyzes the cleavage of type II collagen, the main structural protein in articular cartilage. Excess MMP13 activity causes cartilage degradation in osteoarthritis, making this
Autor:
Johanna Mohlin, Morley D. Hollenberg, Graeme S. Cottrell, Silvia Amadesi, Wolfgang Knecht, Kevin Chapman, Nathalie Vergnolle, Anita Skåregärde, Anders Peterson, Nigel W. Bunnett, Karin Gedda
Publikováno v:
Journal of Biological Chemistry. 282:26089-26100
Although principally produced by the pancreas to degrade dietary proteins in the intestine, trypsins are also expressed in the nervous system and in epithelial tissues, where they have diverse actions that could be mediated by protease-activated rece
Autor:
Andrew P. LeBeau, Alan Hochberg, Deborah A. Lazzarino, Robert J. Romanelli, Clifton G. Fulmer, Teresa L. Wood
Publikováno v:
Journal of Biological Chemistry. 282:22513-22524
Previously we demonstrated that insulin-like growth factor-I mediates the sustained phosphorylation of Akt, which is essential for long term survival and protection of glial progenitors from glutamate toxicity. These prosurvival effects correlated wi
Autor:
Patricio Santillán-Doherty, Armando R. Tovar, Rogelio Hernández-Pando, Lilia Noriega-López, Marcela Gonzalez-Granillo, Bruno Escalante, Nimbe Torres
Publikováno v:
Journal of Biological Chemistry. 282:20657-20666
Obesity is frequently associated with the consumption of high carbohydrate/fat diets leading to hyperinsulinemia. We have demonstrated that soy protein (SP) reduces hyperinsulinemia, but it is unclear by which mechanism. Thus, the purpose of the pres