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Autor:
Gregory R. Steinberg, Paula M. Miotto, Eric A.F. Herbst, Genevieve Simnett, Jamie Whitfield, Holly Robson, Brennan K. Smith, David J. Dyck, Sabina Paglialunga, Graham P. Holloway, Lawrence L. Spriet, Swati S. Jain, Eric M. Desjardins
Publikováno v:
Journal of Biological Chemistry. 292:16653-16664
TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate of 160 kDa (AS160), has been implicated in both insulin- and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase-media
Autor:
Heng Zhang, Xian Wang, Yin Li, Juan Feng, Mingjiang Xu, Changtao Jiang, Yanli Pang, Yang Li, Guoheng Xu, Xinxin Xiang, Wei Kong
Publikováno v:
Journal of Biological Chemistry. 288:9583-9592
Type 2 diabetes is a chronic inflammatory metabolic disease, the key point being insulin resistance. Endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of type 2 diabetes. Previously, we found that hyperhomocysteinemia (HHcy)
Autor:
Deborah Jones, Yudi Soesanto, Glendon J. Parker, Bai Luo, Donald A. McClain, Robert C. Cooksey
Publikováno v:
Journal of Biological Chemistry. 286:26118-26126
The hexosamine biosynthesis pathway (HBP) regulates the post-translational modification of nuclear and cytoplasmic protein by O-linked N-acetylglucosamine (O-GlcNAc). Numerous studies have demonstrated increased flux through this pathway contributes
Autor:
Gul Zaman, Robert M. Kypta, Joanna S. Price, Lance E. Lanyon, Andrew Sunters, V J Armstrong, Yoshiaki Kawano
Publikováno v:
The Journal of Biological Chemistry
The capacity of bones to adjust their mass and architecture to withstand the loads of everyday activity derives from the ability of their resident cells to respond appropriately to the strains engendered. To elucidate the mechanisms of strain respons
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
The pancreatic beta cell is sensitive to even small changes in PDX1 protein levels; consequently, Pdx1 haploinsufficiency can inhibit beta cell growth and decrease insulin biosynthesis and gene expression, leading to compromised glucose-stimulated in
Publikováno v:
Journal of Biological Chemistry, Vol. 284, No 41 (2009) pp. 27892-27898
Obesity and type 2 diabetes present partially overlapping phenotypes with systemic inflammation as a common feature, raising the hypothesis that elevated cytokine levels may contribute to peripheral insulin resistance as well as the decreased beta ce
Publikováno v:
Journal of Biological Chemistry. 284:20398-20407
Continuous macroautophagic activity is critical for the maintenance of neuronal homeostasis; however, unchecked or dysregulated autophagy can lead to cell death. Cultured Purkinje neurons die by an autophagy-associated cell death mechanism when depri
Publikováno v:
Journal of Biological Chemistry. 283:19904-19911
alpha(2)-Macroglobulin (alpha(2)M) is a plasma protease inhibitor, which reversibly binds growth factors and, in its activated form, binds to low density lipoprotein receptor-related protein (LRP-1), an endocytic receptor with cell signaling activity
Publikováno v:
Journal of Biological Chemistry. 282:35179-35186
Recently, single chain peptides have been designed that target the insulin receptor and mimic insulin action. The aim of this study is to explore if activation of the insulin receptor with such an optimized peptide (S597) leads to the same activation
Autor:
Andrew P. LeBeau, Alan Hochberg, Deborah A. Lazzarino, Robert J. Romanelli, Clifton G. Fulmer, Teresa L. Wood
Publikováno v:
Journal of Biological Chemistry. 282:22513-22524
Previously we demonstrated that insulin-like growth factor-I mediates the sustained phosphorylation of Akt, which is essential for long term survival and protection of glial progenitors from glutamate toxicity. These prosurvival effects correlated wi