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pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Linh X. Doan, Hikokazu Suzuki, Rupert C. Wilmouth, Ian J. Clifton, Christopher J. Schofield, Maya Topf, Mark C. Sleeman
Publikováno v:
Journal of Biological Chemistry. 278:20843-20850
The proposed biosynthetic pathway to the carbapenem antibiotics proceeds via epimerization/desaturation of a carbapenam in an unusual process catalyzed by an iron- and 2-oxoglutarate-dependent oxygenase, CarC. Crystal structures of CarC complexed wit