Zobrazeno 1 - 7
of 7
pro vyhledávání: ''
Autor:
Heng Zhang, Xian Wang, Yin Li, Juan Feng, Mingjiang Xu, Changtao Jiang, Yanli Pang, Yang Li, Guoheng Xu, Xinxin Xiang, Wei Kong
Publikováno v:
Journal of Biological Chemistry. 288:9583-9592
Type 2 diabetes is a chronic inflammatory metabolic disease, the key point being insulin resistance. Endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of type 2 diabetes. Previously, we found that hyperhomocysteinemia (HHcy)
Autor:
Deborah Jones, Yudi Soesanto, Glendon J. Parker, Bai Luo, Donald A. McClain, Robert C. Cooksey
Publikováno v:
Journal of Biological Chemistry. 286:26118-26126
The hexosamine biosynthesis pathway (HBP) regulates the post-translational modification of nuclear and cytoplasmic protein by O-linked N-acetylglucosamine (O-GlcNAc). Numerous studies have demonstrated increased flux through this pathway contributes
Publikováno v:
Journal of Biological Chemistry, Vol. 284, No 41 (2009) pp. 27892-27898
Obesity and type 2 diabetes present partially overlapping phenotypes with systemic inflammation as a common feature, raising the hypothesis that elevated cytokine levels may contribute to peripheral insulin resistance as well as the decreased beta ce
Publikováno v:
Journal of Biological Chemistry. 279:21294-21301
Cell volume changes critically determine hepatic signal transduction and metabolism. Hepatocyte swelling by insulin contributes to p38(MAPK) activation leading to inhibition of autophagic proteolysis. Recently integrins were shown to sense hypoosmoti
Publikováno v:
Journal of Biological Chemistry. 279:12777-12785
Previous studies have shown that the endosomal apparatus plays an important role in insulin signaling. Inhibition of endosomal acidification leads to a decrease in insulin-insulin receptor kinase (IRK) dissociation and insulin degradation. Thus, vacu
Autor:
Yuqing E. Chen, Hui Zheng, Yan Xiao, Mukaila A. Akinbami, Mingui Fu, Yongshan Mou, Qian Wang, Jifeng Zhang, Xiaojun Zhu
Publikováno v:
Journal of Biological Chemistry. 277:11505-11512
Although peroxisome proliferator-activated receptor (PPAR) delta is widely expressed in many tissues, the role of PPARdelta is poorly understood. In this study, we report that PPARdelta was up-regulated in vascular smooth muscle cells (VSMC) during v
Autor:
Daming Huang, Michi M. Shinohara, Allan Z. Zhao, Karin E. Bornfeldt, Joseph A. Beavo, Edwin G. Krebs, Masami Shimizu, Hagit Eldar-Finkelman
Publikováno v:
Journal of Biological Chemistry. 275:11348-11354
Although many effects of leptin are mediated through the central nervous system, leptin can regulate metabolism through a direct action on peripheral tissues, such as fat and liver. We show here that leptin, at physiological concentrations, acts thro