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Autor:
Gregory R. Steinberg, Paula M. Miotto, Eric A.F. Herbst, Genevieve Simnett, Jamie Whitfield, Holly Robson, Brennan K. Smith, David J. Dyck, Sabina Paglialunga, Graham P. Holloway, Lawrence L. Spriet, Swati S. Jain, Eric M. Desjardins
Publikováno v:
Journal of Biological Chemistry. 292:16653-16664
TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate of 160 kDa (AS160), has been implicated in both insulin- and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase-media
Autor:
Heng Zhang, Xian Wang, Yin Li, Juan Feng, Mingjiang Xu, Changtao Jiang, Yanli Pang, Yang Li, Guoheng Xu, Xinxin Xiang, Wei Kong
Publikováno v:
Journal of Biological Chemistry. 288:9583-9592
Type 2 diabetes is a chronic inflammatory metabolic disease, the key point being insulin resistance. Endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of type 2 diabetes. Previously, we found that hyperhomocysteinemia (HHcy)
Autor:
Deborah Jones, Yudi Soesanto, Glendon J. Parker, Bai Luo, Donald A. McClain, Robert C. Cooksey
Publikováno v:
Journal of Biological Chemistry. 286:26118-26126
The hexosamine biosynthesis pathway (HBP) regulates the post-translational modification of nuclear and cytoplasmic protein by O-linked N-acetylglucosamine (O-GlcNAc). Numerous studies have demonstrated increased flux through this pathway contributes
Autor:
Gul Zaman, Robert M. Kypta, Joanna S. Price, Lance E. Lanyon, Andrew Sunters, V J Armstrong, Yoshiaki Kawano
Publikováno v:
The Journal of Biological Chemistry
The capacity of bones to adjust their mass and architecture to withstand the loads of everyday activity derives from the ability of their resident cells to respond appropriately to the strains engendered. To elucidate the mechanisms of strain respons
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
The pancreatic beta cell is sensitive to even small changes in PDX1 protein levels; consequently, Pdx1 haploinsufficiency can inhibit beta cell growth and decrease insulin biosynthesis and gene expression, leading to compromised glucose-stimulated in
Publikováno v:
Journal of Biological Chemistry, Vol. 284, No 41 (2009) pp. 27892-27898
Obesity and type 2 diabetes present partially overlapping phenotypes with systemic inflammation as a common feature, raising the hypothesis that elevated cytokine levels may contribute to peripheral insulin resistance as well as the decreased beta ce
Publikováno v:
Journal of Biological Chemistry. 282:35179-35186
Recently, single chain peptides have been designed that target the insulin receptor and mimic insulin action. The aim of this study is to explore if activation of the insulin receptor with such an optimized peptide (S597) leads to the same activation
Publikováno v:
Journal of Biological Chemistry. 281:25915-25925
In response to growth factors, vascular smooth muscle cells (VSMCs) undergo a phenotypic modulation from a contractile, non-proliferative state to an activated, migratory state. This transition is characterized by changes in their gene expression pro
Autor:
Gérard Waeber, Christian Widmann, Joël Walicki, Amar Abderrahmani, Jiang-Yan Yang, Bernard Thorens, Marion Cornu
Publikováno v:
Journal of Biological Chemistry. 280:32835-32842
Apoptosis of pancreatic beta cells is implicated in the onset of type 1 and type 2 diabetes. Consequently, strategies aimed at increasing the resistance of beta cells toward apoptosis could be beneficial in the treatment of diabetes. RasGAP, a regula
Publikováno v:
Journal of Biological Chemistry. 280:9887-9894
Insulin resistance and increased cytochrome P450 2E1 (CYP2E1) expression are both associated with and mechanistically implicated in the development of nonalcoholic fatty liver disease. Although currently viewed as distinct factors, insulin resistance