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Autor:
Patrice Fort, Thomas W. Gardner, Ravi S.J. Singh, Hisanori Imai, Sergey N. Zolov, Mandy K. Losiewicz
Publikováno v:
The Journal of Biological Chemistry
The retinal insulin receptor (IR) exhibits basal kinase activity equivalent to that of the liver of fed animals, but unlike the liver, does not fluctuate with feeding and fasting; it also declines rapidly after the onset of insulin-deficient diabetes
Autor:
James L. Dillon, Ranna Ardebili, Danielle N. Miranda, D.P. Baluch, Paul R. Langlais, Xitao Xie, April Mengos, Bradlee L. Heckmann, Lawrence J. Mandarino, Jun Liu
Publikováno v:
Journal of Biological Chemistry. 287:39245-39253
Insulin stimulates the mobilization of glucose transporter 4 (GLUT4) storage vesicles to the plasma membrane, resulting in an influx of glucose into target tissues such as muscle and fat. We present evidence that CLIP-associating protein 2 (CLASP2),
Autor:
Elizabeth Zielinski, Thomas Scherer, Nika Filatova, James O'Hare, Christoph Buettner, Claudia Lindtner
Publikováno v:
Journal of Biological Chemistry. 287:33061-33069
Insulin controls fatty acid (FA) release from white adipose tissue (WAT) through direct effects on adipocytes and indirectly through hypothalamic signaling by reducing sympathetic nervous system outflow to WAT. Uncontrolled FA release from WAT promot
Autor:
Amin Ardestani, Jose Oberholzer, Jae Hyoung Cho, Piero Marchetti, Federico Paroni, Gitanjali Dharmadhikari, Julie Kerr Conte, Roberto Lupi, Kathrin Maedler, Nadine S. Sauter
Publikováno v:
Journal of Biological Chemistry. 286:17144-17155
The transcription factor PDX1 plays a critical role during β-cell development and in glucose-induced insulin gene transcription in adult β-cells. Acute glucose exposure leads to translocalization of PDX1 to the nucleoplasm, whereas under conditions
Publikováno v:
Journal of Biological Chemistry. 286:8287-8296
In this study, we explored the coordinate regulation of mTORC1 by insulin and amino acids. Rat livers were perfused with medium containing various concentrations of insulin and/or amino acids. At fasting (1×) or 2× (2×AA) concentrations of amino a
Publikováno v:
Journal of Biological Chemistry. 285:25904-25912
The aim of the study was to analyze whether the proliferative effects of insulin in rat liver involve cross-signaling toward the epidermal growth factor receptor (EGFR) and whether this is mediated by insulin-induced hepatocyte swelling. Studies were
Publikováno v:
Journal of Biological Chemistry, Vol. 284, No 41 (2009) pp. 27892-27898
Obesity and type 2 diabetes present partially overlapping phenotypes with systemic inflammation as a common feature, raising the hypothesis that elevated cytokine levels may contribute to peripheral insulin resistance as well as the decreased beta ce
Autor:
William L. Klein, Wei Qin Zhao, Pascale N. Lacor, Hui Chen, Michael J. Quon, Grant A. Krafft, Mary P. Lambert
Publikováno v:
Journal of Biological Chemistry. 284:18742-18753
Accumulation of amyloid beta (Abeta) oligomers in the brain is toxic to synapses and may play an important role in memory loss in Alzheimer disease. However, how these toxins are built up in the brain is not understood. In this study we investigate w
Publikováno v:
Journal of Biological Chemistry. 284:5289-5298
Chronic hyperglycemia contributes to pancreatic beta-cell dysfunction during the development of type 2 diabetes. Treatment of pancreatic beta-cells with prolonged high glucose concentrations has been shown to reduce insulin promoter activity and insu
Autor:
Clair L. Alvino, Lisbeth Gauguin, Pierre De Meyts, Briony E. Forbes, Kerrie A. McNeil, Carlie Delaine, John C. Wallace
Publikováno v:
Journal of Biological Chemistry. 283:20821-20829
Current evidence supports a binding model in which the insulin molecule contains two binding surfaces, site 1 and site 2, which contact the two halves of the insulin receptor. The interaction of these two surfaces with the insulin receptor results in