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Publikováno v:
Journal of Biological Chemistry. 272:14542-14546
Rab4, a member of the Rab family of Ras-related small GTP-binding proteins, has been shown to be associated with GLUT4-containing vesicles and implicated in the insulin action on glucose transport in rat adipocytes. In the present study, we investiga
Autor:
Sylvia White-Carrington, David E. Moller, Joel P. Berger, Subarna Biswas, Gaochao Zhou, Alex Elbrecht, Deborah Szalkowski, Bei Zhang
Publikováno v:
Journal of Biological Chemistry. 271:31771-31774
Peroxisome proliferator-activated receptor (PPAR) gamma plays an important role in adipocyte differentiation and the regulation of adipocyte gene expression. Insulin also serves to promote adipogenesis. We report that insulin and a PPARgamma ligand (
Publikováno v:
Journal of Biological Chemistry. 271:24418-24424
Treatment of rat hepatoma cells with insulin attenuated the interleukin 6 (IL-6) stimulation of acute phase plasma protein genes. To identify the potential mechanism of this action, the influence of insulin on IL-6 signal transduction was determined.
Publikováno v:
Journal of Biological Chemistry. 271:16690-16694
The hexokinases, by converting glucose to glucose 6-phosphate, help maintain the glucose concentration gradient that results in the movement of glucose into cells through the facilitative glucose transporters. Hexokinase II (HKII) is the major hexoki
Autor:
K. Carel, Jane E.B. Reusch, Penney Hsieh, Boris Draznin, David DePaolo, J. Wayne Leitner, Penpun Bhuripanyo
Publikováno v:
Journal of Biological Chemistry. 270:2036-2040
To evaluate the role of the "Ras pathway" in mediating metabolic signaling by insulin, we employed lovastatin to exhibit isoprenilation of Ras proteins in Rat-1 fibroblasts transfected with human insulin receptors (HIRc cells) and in differentiated 3
Autor:
Katsunori Tsukuda, Tomoichiro Asano, Hisamitsu Ishihara, Motonobu Anai, Yoshio Yazaki, Masatoshi Kikuchi, J.-I. Miyazaki, Hideki Katagiri, Yoshitomo Oka, Kouichi Inukai
Publikováno v:
Journal of Biological Chemistry. 269:3081-3087
The recently established pancreatic beta-cell line MIN6 retains the ability to secrete insulin in response to physiological glucose concentrations. To investigate the role of glucose transport and phosphorylation in glucose-stimulated insulin secreti
Publikováno v:
Journal of Biological Chemistry. 268:26055-26058
Tumor necrosis factor-alpha (TNF) has recently been shown to induce insulin resistance. We have examined the possible effect of TNF on the early events in insulin transmembrane signaling. Incubation of the insulin-sensitive rat hepatoma Fao cells wit
Publikováno v:
Journal of Biological Chemistry. 268:7917-7922
Previous studies have shown that a human insulin receptor lacking the COOH-terminal 43-amino acid domain (HIR delta CT) displays a compromised ability to stimulate glucose transport and glycogen synthase, whereas mitogenic signaling and stimulation o
Autor:
Assia Shisheva, Yoram Shechter
Publikováno v:
Journal of Biological Chemistry. 268:6463-6469
In previous studies we have identified a cytosolic protein tyrosine kinase (CytPTK) in rat adipocytes that is largely activated in vanadate-pretreated cells (Shisheva, A., and Shechter, Y. (1992) FEBS Lett. 300, 93-96). We report here that staurospor
Publikováno v:
Journal of Biological Chemistry. 268:3805-3808
Insulin has been shown to be important for normal liver regeneration to occur. The mechanisms whereby insulin may exert its effects on hepatocyte growth, however, are still unknown. The rat and human insulin receptor substrate 1 (IRS-1) is a specific