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Autor:
Patrice Fort, Thomas W. Gardner, Ravi S.J. Singh, Hisanori Imai, Sergey N. Zolov, Mandy K. Losiewicz
Publikováno v:
The Journal of Biological Chemistry
The retinal insulin receptor (IR) exhibits basal kinase activity equivalent to that of the liver of fed animals, but unlike the liver, does not fluctuate with feeding and fasting; it also declines rapidly after the onset of insulin-deficient diabetes
Autor:
William L. Klein, Wei Qin Zhao, Pascale N. Lacor, Hui Chen, Michael J. Quon, Grant A. Krafft, Mary P. Lambert
Publikováno v:
Journal of Biological Chemistry. 284:18742-18753
Accumulation of amyloid beta (Abeta) oligomers in the brain is toxic to synapses and may play an important role in memory loss in Alzheimer disease. However, how these toxins are built up in the brain is not understood. In this study we investigate w
Autor:
Lisbeth Gauguin, Briony E. Forbes, Birgit Klaproth, Kerrie A. McNeil, Asser Sloth Andersen, Waseem Sajid, Pierre De Meyts
Publikováno v:
Journal of Biological Chemistry. 283:2604-2613
Insulin and the insulin-like growth factors (IGFs) bind with high affinity to their cognate receptor and with lower affinity to the noncognate receptor. The major structural difference between insulin and the IGFs is that the IGFs are single chain po
Publikováno v:
Journal of Biological Chemistry. 282:35179-35186
Recently, single chain peptides have been designed that target the insulin receptor and mimic insulin action. The aim of this study is to explore if activation of the insulin receptor with such an optimized peptide (S597) leads to the same activation
Publikováno v:
Journal of Biological Chemistry. 279:39348-39357
Compartmentalization of signaling molecules may explain, at least in part, how insulin or growth factors achieve specificity. Caveolae/rafts are specialized lipid compartments that have been implicated in insulin signaling. In the present study, we i
Endosomal Proteolysis of Internalized Insulin at the C-terminal Region of the B Chain by Cathepsin D
Publikováno v:
Journal of Biological Chemistry. 277:9437-9446
The endosomal compartment of hepatic parenchymal cells contains an acidic endopeptidase, endosomal acidic insulinase, which hydrolyzes internalized insulin and generates the major primary end product A(1--21)-B(1--24) insulin resulting from a major c
Autor:
Makoto Nakamura, Chad E.N. Reiter, Thomas W. Gardner, David A. Antonetti, Alistair J. Barber, Gail M. Seigel, E. B. Wolpert
Publikováno v:
Journal of Biological Chemistry. 276:32814-32821
The ability of insulin to protect neurons from apoptosis was examined in differentiated R28 cells, a neural cell line derived from the neonatal rat retina. Apoptosis was induced by serum deprivation, and the number of pyknotic cells was counted. p53
Autor:
Victor D.-H. Ding, Dan Xie, Kun Liu, Dawn E. Biazzo-Ashnault, Libo Xu, Xiaolan Shen, James V. Heck, Su Er W Huskey, A. Brian Jones, David E. Moller, Richard Saperstein, Zhihua Li, Bei B. Zhang, Deborah Szalkowski, Edward J. Brady, Gino Salituro, Sajjad A. Qureshi
Publikováno v:
Journal of Biological Chemistry. 275:36590-36595
We recently described the identification of a non-peptidyl fungal metabolite (l-783,281, compound 1), which induced activation of human insulin receptor (IR) tyrosine kinase and mediated insulin-like effects in cells, as well as decreased blood gluco
Publikováno v:
Journal of Biological Chemistry. 273:22194-22200
pp120, a substrate of the insulin receptor tyrosine kinase, is a plasma membrane glycoprotein that is expressed in the hepatocyte as two spliced isoforms differing by the presence (full-length) or absence (truncated) of most of the intracellular doma
Autor:
Yoshiteru Jinnouchi, Kazuyoshi Ikeda, Kenshi Matsumoto, Jukka Melkko, Takayuki Higashi, Hiroyuki Sano, Hideichi Makino, Yousuke Ebina, Seikoh Horiuchi, Bård Smedsrød
Publikováno v:
Journal of Biological Chemistry. 273:8630-8637
Hyperglycemia accelerates the formation and accumulation of advanced glycation end products (AGE) in plasma and tissue, which may cause diabetic vascular complications. We recently reported that scavenger receptors expressed by liver endothelial cell