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Autor:
Karim Bouzakri, Katharina Rickenbach, Caroline Arous, Michel Pinget, Bernhard Wehrle-Haller, Maria L. Mizgier
Publikováno v:
Journal of Biological Chemistry, Vol. 295, No 49 (2020) pp. 16510-16528
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Elevated levels of fasting insulin release and insufficient glucose-stimulated insulin secretion (GSIS) are hallmarks of diabetes. Studies have established cross-talk between integrin signaling and insulin activity, but more details of how integrin-d
Autor:
Keitaro Yamanouchi, Shiro Minami, Katsuyuki Nakamura, Hidetoshi Sugihara, Reiko Tokita, Hisanori Kato, Yuka Toyoshima, Naomi Teramoto
Publikováno v:
J Biol Chem
Insulin receptor substrate (IRS)-2, along with IRS-1, is a key signaling molecule that mediates the action of insulin and insulin-like growth factor (IGF)-I. The activated insulin and IGF-I receptors phosphorylate IRSs on tyrosine residues, leading t
Autor:
Daniel J. Fazakerley, Alexis Díaz-Vegas, Sarah D. Elkington, Gregory J. Cooney, David E. James, Kelsey H. Fisher-Wellman, James G. Burchfield, James R. Krycer, Kristen C. Cooke
Publikováno v:
J Biol Chem
Insulin action in adipose tissue is crucial for whole-body glucose homeostasis, with insulin resistance being a major risk factor for metabolic diseases such as type 2 diabetes. Recent studies have proposed mitochondrial oxidants as a unifying driver
Autor:
Zhuo Xian Meng, Xingjiang Mu, Jiangtong Peng, Yutian Li, Tianqing Peng, Xiaohong Wang, Shan Deng, Guo-Chang Fan, Kobina Essandoh
Publikováno v:
J Biol Chem
The initiation and development of diabetes are mainly ascribed to the loss of functional β-cells. Therapies designed to regenerate β-cells provide great potential for controlling glucose levels and thereby preventing the devastating complications a
Publikováno v:
Journal of Biological Chemistry. 293:8578-8587
Tankyrase 1 and 2, members of the poly(ADP-ribose) polymerase family, have previously been shown to play a role in insulin-mediated glucose uptake in adipocytes. However, their precise mechanism of action, and their role in insulin action in other ce
Autor:
Runping Fang, Xiaodong Zhang, Hui Shi, Hang Li, Zhen Wang, Lihong Ye, Yinghui Li, Weiying Zhang, Huawei Wang
Publikováno v:
Journal of Biological Chemistry. 293:2053-2065
The activation of insulin gene transcription depends on multiple nuclear proteins, including the transcription factors PDX-1 and NEUROD1, which form a transcriptional complex. We recently reported that hepatitis B X-interacting protein (HBXIP, also t
Autor:
Mei Yang, Fei Gao, Yuqin Chen, Chunyu Wang, Tingjie Li, Xueting He, Hui Liu, Maoqi Wang, Jiaojiao Hou, Zhuoyuan Yu, Jiang Tan, Xiaoyan Liu
Publikováno v:
The Journal of Biological Chemistry
Metformin is the first-line antidiabetic agent for type 2 diabetes mellitus (T2DM) treatment. Although accumulated evidence has shed light on the consequences of metformin action, the precise mechanisms of its action, especially in the pancreas, are
Autor:
Gregory R. Steinberg, Paula M. Miotto, Eric A.F. Herbst, Genevieve Simnett, Jamie Whitfield, Holly Robson, Brennan K. Smith, David J. Dyck, Sabina Paglialunga, Graham P. Holloway, Lawrence L. Spriet, Swati S. Jain, Eric M. Desjardins
Publikováno v:
Journal of Biological Chemistry. 292:16653-16664
TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate of 160 kDa (AS160), has been implicated in both insulin- and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase-media
Publikováno v:
Journal of Biological Chemistry. 292:5239-5252
Previous studies have shown that glucagon cooperatively interacts with insulin to stimulate hepatic FGF21 gene expression. Here we investigated the mechanism by which glucagon and insulin increased FGF21 gene transcription in primary hepatocyte cultu
Publikováno v:
Journal of Biological Chemistry. 291:18440-18452
Altered microRNA profiles have been demonstrated in experimental models of type 2 diabetes, including in islets of the diabetic Goto-Kakizaki (GK) rat. Our bioinformatic analysis of conserved sequences in promoters of microRNAs, previously observed t