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Publikováno v:
Journal of Biological Chemistry. 291:18440-18452
Altered microRNA profiles have been demonstrated in experimental models of type 2 diabetes, including in islets of the diabetic Goto-Kakizaki (GK) rat. Our bioinformatic analysis of conserved sequences in promoters of microRNAs, previously observed t
Publikováno v:
Journal of Biological Chemistry. 295:2885
Insulin is known to induce hepatocyte swelling, which triggers via integrins and c-Src kinase an activation of the epidermal growth factor receptor (EGFR) and subsequent cell proliferation (1). Free fatty acids (FFAs) are known to induce lipoapoptosi
Autor:
Jesús Ruberte, Laia Vilà, Estefania Casana, Veronica Jimenez, Maria Molas, Mercè Obach, Judith Agudo, Fatima Bosch, Ariana Salavert, Alba Casellas, Cristina Mallol, Virginia Haurigot, Ricardo Lage, Miquel Garcia, Meritxell Morró
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Universitat Autònoma de Barcelona
The human insulin-like growth factor 2 (IGF2) and insulin genes are located within the same genomic region. Although human genomic studies have demonstrated associations between diabetes and the insulin/IGF2 locus or the IGF2 mRNA-binding protein 2 (
Autor:
Austin M. Rountree, Sarah A. White, Francis Kim, Dan S. Luciani, Ian R. Sweet, Jared Radtke, Mark Lisowski, Adam S. Neal, Christiane S. Hampe, Norma O. Rizzo
Publikováno v:
Journal of Biological Chemistry. 289:19110-19119
The aim of the study was to assess the relative control of insulin secretion rate (ISR) by calcium influx and signaling from cytochrome c in islets where, as in diabetes, the metabolic pathways are impaired. This was achieved either by culturing isol
Autor:
Barbara C. McGrath, Michael W. Roe, Douglas R. Cavener, Rong Wang, Gong Chen, Richard F. Kopp, Xin Tang
Publikováno v:
Journal of Biological Chemistry. 288:33824-33836
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) (EIF2AK3) is essential for normal development and function of the insulin-secreting β-cell. Although genetic ablation of PERK in β-cells results in permanent neonatal diabetes in human
Autor:
Mark O. Huising, Danhong Lu, Hans E. Hohmeier, Paul B. Rosenberg, Hengtao Zhang, Mette V. Jensen, Christopher B. Newgard, Wylie Vale, Jonathan M. Haldeman
Publikováno v:
Journal of Biological Chemistry. 288:23128-23140
Recent studies have shown that the pyruvate-isocitrate cycling pathway, involving the mitochondrial citrate/isocitrate carrier and the cytosolic NADP-dependent isocitrate dehydrogenase (ICDc), is involved in control of glucose-stimulated insulin secr
Autor:
Heng Zhang, Xian Wang, Yin Li, Juan Feng, Mingjiang Xu, Changtao Jiang, Yanli Pang, Yang Li, Guoheng Xu, Xinxin Xiang, Wei Kong
Publikováno v:
Journal of Biological Chemistry. 288:9583-9592
Type 2 diabetes is a chronic inflammatory metabolic disease, the key point being insulin resistance. Endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of type 2 diabetes. Previously, we found that hyperhomocysteinemia (HHcy)
Autor:
James L. Dillon, Ranna Ardebili, Danielle N. Miranda, D.P. Baluch, Paul R. Langlais, Xitao Xie, April Mengos, Bradlee L. Heckmann, Lawrence J. Mandarino, Jun Liu
Publikováno v:
Journal of Biological Chemistry. 287:39245-39253
Insulin stimulates the mobilization of glucose transporter 4 (GLUT4) storage vesicles to the plasma membrane, resulting in an influx of glucose into target tissues such as muscle and fat. We present evidence that CLIP-associating protein 2 (CLASP2),
Autor:
Elizabeth Zielinski, Thomas Scherer, Nika Filatova, James O'Hare, Christoph Buettner, Claudia Lindtner
Publikováno v:
Journal of Biological Chemistry. 287:33061-33069
Insulin controls fatty acid (FA) release from white adipose tissue (WAT) through direct effects on adipocytes and indirectly through hypothalamic signaling by reducing sympathetic nervous system outflow to WAT. Uncontrolled FA release from WAT promot
Publikováno v:
Journal of Biological Chemistry. 287:6350-6361
Neurexins are a family of transmembrane, synaptic adhesion molecules. In neurons, neurexins bind to both sub-plasma membrane and synaptic vesicle-associated constituents of the secretory machinery, play a key role in the organization and stabilizatio