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Publikováno v:
Journal of Biological Chemistry. 291:18440-18452
Altered microRNA profiles have been demonstrated in experimental models of type 2 diabetes, including in islets of the diabetic Goto-Kakizaki (GK) rat. Our bioinformatic analysis of conserved sequences in promoters of microRNAs, previously observed t
Publikováno v:
Journal of Biological Chemistry. 295:2885
Insulin is known to induce hepatocyte swelling, which triggers via integrins and c-Src kinase an activation of the epidermal growth factor receptor (EGFR) and subsequent cell proliferation (1). Free fatty acids (FFAs) are known to induce lipoapoptosi
Autor:
Martine Vaxillaire, Ghislaine Fontés, Jared Rutter, Vincent Poitout, J. Philippe, Sarah Fogarty, Philippe Froguel, Frédérique Diraison, Richard B. Sessions, Meriem Semache, Francesca Semplici, Amélie Bonnefond, Guy A. Rutter, Gargi Meur
Publikováno v:
The Journal of Biological Chemistry
Background: The glucose sensor PAS kinase (PASK) plays a fundamental role in pancreatic islet physiology. Results: A single amino acid substitution in the human PASK kinase domain stimulates enzyme activity and increases insulin secretion at low gluc
Publikováno v:
Journal of Biological Chemistry, Vol. 284, No 41 (2009) pp. 27892-27898
Obesity and type 2 diabetes present partially overlapping phenotypes with systemic inflammation as a common feature, raising the hypothesis that elevated cytokine levels may contribute to peripheral insulin resistance as well as the decreased beta ce
Publikováno v:
Journal of Biological Chemistry. 282:10341-10351
The AMP-activated protein kinase (AMPK) is a central regulator of the energy status of the cell, based on its unique ability to respond directly to fluctuations in the ratio of AMP:ATP. Because glucose and amino acids stimulate insulin release from p
Autor:
Gérard Waeber, Christian Widmann, Joël Walicki, Amar Abderrahmani, Jiang-Yan Yang, Bernard Thorens, Marion Cornu
Publikováno v:
Journal of Biological Chemistry. 280:32835-32842
Apoptosis of pancreatic beta cells is implicated in the onset of type 1 and type 2 diabetes. Consequently, strategies aimed at increasing the resistance of beta cells toward apoptosis could be beneficial in the treatment of diabetes. RasGAP, a regula
Publikováno v:
Journal of Biological Chemistry. 280:32413-32418
Abnormalities in lipid metabolism have been proposed as contributing factors to both defective insulin secretion from the pancreatic beta cell and peripheral insulin resistance in type 2 diabetes. Previously, we have shown that prolonged exposure of
Publikováno v:
Journal of Biological Chemistry. 279:21294-21301
Cell volume changes critically determine hepatic signal transduction and metabolism. Hepatocyte swelling by insulin contributes to p38(MAPK) activation leading to inhibition of autophagic proteolysis. Recently integrins were shown to sense hypoosmoti
Autor:
Susan D. Parazzoli, Cynthia L. Kelpe, Vincent Poitout, Barton Luke Wicksteed, Christopher J. Rhodes, Patrick C. Moore
Publikováno v:
Journal of Biological Chemistry. 278:30015-30021
Chronic exposure to elevated levels of fatty acids impairs pancreatic beta cell function, a phenomenon thought to contribute to the progressive deterioration of insulin secretion in type 2 diabetes. We have previously demonstrated that prolonged expo
Publikováno v:
Journal of Biological Chemistry. 277:6559-6566
Insulin treatment of rat adipocytes increases both cytoplasmic alkalinity and glucose transport activity. Both processes are blocked by the phosphatidylinositol 3-kinase inhibitor wortmannin. Isoproterenol pre-treatment reverses the alkalinizing effe