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Autor:
Daniel J. Fazakerley, Alexis Díaz-Vegas, Sarah D. Elkington, Gregory J. Cooney, David E. James, Kelsey H. Fisher-Wellman, James G. Burchfield, James R. Krycer, Kristen C. Cooke
Publikováno v:
J Biol Chem
Insulin action in adipose tissue is crucial for whole-body glucose homeostasis, with insulin resistance being a major risk factor for metabolic diseases such as type 2 diabetes. Recent studies have proposed mitochondrial oxidants as a unifying driver
Autor:
Gregory R. Steinberg, Paula M. Miotto, Eric A.F. Herbst, Genevieve Simnett, Jamie Whitfield, Holly Robson, Brennan K. Smith, David J. Dyck, Sabina Paglialunga, Graham P. Holloway, Lawrence L. Spriet, Swati S. Jain, Eric M. Desjardins
Publikováno v:
Journal of Biological Chemistry. 292:16653-16664
TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate of 160 kDa (AS160), has been implicated in both insulin- and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase-media
Autor:
Austin M. Rountree, Sarah A. White, Francis Kim, Dan S. Luciani, Ian R. Sweet, Jared Radtke, Mark Lisowski, Adam S. Neal, Christiane S. Hampe, Norma O. Rizzo
Publikováno v:
Journal of Biological Chemistry. 289:19110-19119
The aim of the study was to assess the relative control of insulin secretion rate (ISR) by calcium influx and signaling from cytochrome c in islets where, as in diabetes, the metabolic pathways are impaired. This was achieved either by culturing isol
Autor:
Barbara C. McGrath, Michael W. Roe, Douglas R. Cavener, Rong Wang, Gong Chen, Richard F. Kopp, Xin Tang
Publikováno v:
Journal of Biological Chemistry. 288:33824-33836
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) (EIF2AK3) is essential for normal development and function of the insulin-secreting β-cell. Although genetic ablation of PERK in β-cells results in permanent neonatal diabetes in human
Autor:
Mark O. Huising, Danhong Lu, Hans E. Hohmeier, Paul B. Rosenberg, Hengtao Zhang, Mette V. Jensen, Christopher B. Newgard, Wylie Vale, Jonathan M. Haldeman
Publikováno v:
Journal of Biological Chemistry. 288:23128-23140
Recent studies have shown that the pyruvate-isocitrate cycling pathway, involving the mitochondrial citrate/isocitrate carrier and the cytosolic NADP-dependent isocitrate dehydrogenase (ICDc), is involved in control of glucose-stimulated insulin secr
Autor:
Heng Zhang, Xian Wang, Yin Li, Juan Feng, Mingjiang Xu, Changtao Jiang, Yanli Pang, Yang Li, Guoheng Xu, Xinxin Xiang, Wei Kong
Publikováno v:
Journal of Biological Chemistry. 288:9583-9592
Type 2 diabetes is a chronic inflammatory metabolic disease, the key point being insulin resistance. Endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of type 2 diabetes. Previously, we found that hyperhomocysteinemia (HHcy)
Autor:
Elizabeth Zielinski, Thomas Scherer, Nika Filatova, James O'Hare, Christoph Buettner, Claudia Lindtner
Publikováno v:
Journal of Biological Chemistry. 287:33061-33069
Insulin controls fatty acid (FA) release from white adipose tissue (WAT) through direct effects on adipocytes and indirectly through hypothalamic signaling by reducing sympathetic nervous system outflow to WAT. Uncontrolled FA release from WAT promot
Publikováno v:
Journal of Biological Chemistry. 287:6350-6361
Neurexins are a family of transmembrane, synaptic adhesion molecules. In neurons, neurexins bind to both sub-plasma membrane and synaptic vesicle-associated constituents of the secretory machinery, play a key role in the organization and stabilizatio
Autor:
Francis Kim, Ian R. Sweet, David M. Hockenbery, Daciana Margineantu, Drew Couron, Iok Teng Kuok, Norma O. Rizzo, Seung-Ryoung Jung
Publikováno v:
Journal of Biological Chemistry. 286:17422-17434
Influx of calcium is an essential but insufficient signal in sustained nutrient-stimulated insulin secretion, and increased metabolic rate of the beta cell is also required. The aim of the study was to test the hypothesis that the reduced state of cy
Publikováno v:
Journal of Biological Chemistry. 286:8287-8296
In this study, we explored the coordinate regulation of mTORC1 by insulin and amino acids. Rat livers were perfused with medium containing various concentrations of insulin and/or amino acids. At fasting (1×) or 2× (2×AA) concentrations of amino a