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Publikováno v:
Journal of Biological Chemistry. 295:15454-15463
The ferric uptake regulator (Fur) is a global transcription factor that regulates intracellular iron homeostasis in bacteria. The current hypothesis states that when the intracellular "free" iron concentration is elevated, Fur binds ferrous iron, and
Autor:
Angela L. Picciano, Brian R. Crane
Publikováno v:
Journal of Biological Chemistry. 294:10708-10719
Nitric oxide synthases (NOSs) are heme-based monooxygenases that convert l-Arg to l-citrulline and nitric oxide (NO), a key signaling molecule and cytotoxic agent in mammals. Bacteria also contain NOS proteins, but the role of NO production within th
Publikováno v:
Journal of Biological Chemistry. 294:1891-1903
The antibiotic trimethoprim is frequently used to manage Burkholderia infections, and members of the resistance-nodulation-division (RND) family of efflux pumps have been implicated in multidrug resistance of this species complex. We show here that a
Publikováno v:
Journal of Biological Chemistry. 293:4350-4365
Polymyxins such as colistin are antibiotics used as a final line of defense in the management of infections with multidrug-resistant Gram-negative bacteria. Although natural resistance to polymyxins is rare, the discovery of a mobilized colistin resi
Autor:
Christoffer Brasen, Arpan Sharma, Moazur Rahman, Mazhar Iqbal, Aqsa Shaheen, Nanda G. Aduri, Osman Mirza, Paul R. Hansen, Bala K. Prabhala, Michael Gajhede, Neha Sharma
Publikováno v:
Journal of Biological Chemistry. 293:1007-1017
Chloramphenicol (Cam) is a broad-spectrum antibiotic used to combat bacterial infections in humans and animals. Cam export from bacterial cells is one of the mechanisms by which pathogens resist Cam's antibacterial effects, and several different prot
Autor:
Roland Lill
Publikováno v:
J Biol Chem
The ferric uptake regulator (Fur) is a global transcription factor that regulates intracellular iron homeostasis in bacteria. The current hypothesis states that when the intracellular “free” iron concentration is elevated, Fur binds ferrous iron,
Autor:
Orville A. Pemberton, David M. Boragine, Timothy Palzkill, Shrenik C. Mehta, Yu Chen, Ian M. Furey
Publikováno v:
The Journal of Biological Chemistry
Serine active-site β-lactamases hydrolyze β-lactam antibiotics through the formation of a covalent acyl-enzyme intermediate followed by deacylation via an activated water molecule. Carbapenem antibiotics are poorly hydrolyzed by most β-lactamases
Autor:
Mathias Winterhalter, Malcolm G. P. Page, Lucile Moynié, Harsha Bajaj, Matteo Ceccarelli, James H. Naismith, Mariano Andrea Scorciapino
Publikováno v:
Journal of Biological Chemistry. 291:2837-2847
Integral membrane proteins known as porins are the major pathway by which hydrophilic antibiotics cross the outer membrane of Gram-negative bacteria. Single point mutations in porins can decrease the permeability of an antibiotic, either by reduction
Autor:
Liping Wang, Shihyun You, Ninad V. Prabhu, Hongfeng Deng, Danielle G. Smith, Jing Chai, Ginger H Tomberlin, Robert T. Nolte, James H. Nichols, G. Bruce Wisely, Edgar R. Wood, Cecil E Rise, Hamilton D. Dickson, J. David Taylor, Luz Helena Kryn, Randy K. Bledsoe, Timothy P. Sheahan, Yun Ding, Sarah Harris-Gurley, Eldridge N. Nartey, J. Brad Shotwell, Bing Xia, Philias Daka, Vince Tai
Publikováno v:
Journal of Biological Chemistry
2',5'-Oligoadenylate synthetase (OAS) enzymes and RNase-L constitute a major effector arm of interferon (IFN)-mediated antiviral defense. OAS produces a unique oligonucleotide second messenger, 2',5'-oligoadenylate (2-5A), that binds and activates RN
Autor:
Måns Ehrenberg, Suparna Sanyal, Anneli Borg, Michael Y. Pavlov, Ikue Shiroyama, Vasili Hauryliuk, Mikael Holm
Publikováno v:
Journal of Biological Chemistry. 290:3440-3454
The antibiotic fusidic acid (FA) targets elongation factor G (EF-G) and inhibits ribosomal peptide elongation and ribosome recycling, but deeper mechanistic aspects of FA action have remained unknown. Using quench flow and stopped flow experiments in