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Autor:
Gerhard Müller-Newen, Peter C. Heinrich, Johannes Grossmann, Armin Buschauer, Stephan Kiessling, Martin Hausmann, Jörn Sträter, Jürgen Schölmerich, Felix A. Montero-Julian, Heiko C. Rath, Sandra N. Leeb, Klaus Schlottmann, T. Andus, Gerhard Rogler, T. Spöttl
Publikováno v:
Journal of Biological Chemistry. 279:10304-10315
A tissue-protective effect of interleukin-11 (IL-11) for the intestinal mucosa has been postulated from animal models of inflammatory bowel disease (IBD). Despite the fact that the clinical usefulness of the anti-inflammatory effects of this cytokine
Autor:
Makoto Nakamura, Chad E.N. Reiter, Thomas W. Gardner, David A. Antonetti, Alistair J. Barber, Gail M. Seigel, E. B. Wolpert
Publikováno v:
Journal of Biological Chemistry. 276:32814-32821
The ability of insulin to protect neurons from apoptosis was examined in differentiated R28 cells, a neural cell line derived from the neonatal rat retina. Apoptosis was induced by serum deprivation, and the number of pyknotic cells was counted. p53
Autor:
Daming Huang, Michi M. Shinohara, Allan Z. Zhao, Karin E. Bornfeldt, Joseph A. Beavo, Edwin G. Krebs, Masami Shimizu, Hagit Eldar-Finkelman
Publikováno v:
Journal of Biological Chemistry. 275:11348-11354
Although many effects of leptin are mediated through the central nervous system, leptin can regulate metabolism through a direct action on peripheral tissues, such as fat and liver. We show here that leptin, at physiological concentrations, acts thro
Publikováno v:
Journal of Biological Chemistry. 273:27320-27324
A rat hepatoma cell line, H4IIE, was stably transfected with a tamoxifen regulatable Akt-1 construct. Treatment of these cells with tamoxifen caused a rapid stimulation of Akt enzymatic activity that was comparable with the activity observed with the