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Autor:
Lindsay C. McDermott, Jayesh S. Bhatt, Daniel P. Gale, Stephen J. Perkins, Jayesh Gor, Nilufar Kadkhodayi-Kholghi
Publikováno v:
'Journal of Biological Chemistry ', vol: 295, pages: 16342-16358 (2020)
J Biol Chem
J Biol Chem
The human complement Factor H–related 5 protein (FHR5) antagonizes the main circulating complement regulator Factor H, resulting in the deregulation of complement activation. FHR5 normally contains nine short complement regulator (SCR) domains, but
Publikováno v:
The Journal of Biological Chemistry
The lectin pathway (LP) of the complement system is an important antimicrobial defense mechanism, but it also contributes significantly to ischemia reperfusion injury (IRI) associated with myocardial infarct, stroke, and several other clinical condit
Publikováno v:
Journal of Biological Chemistry. 293:7195-7208
Atypical hemolytic uremic syndrome (aHUS) and bone marrow transplantation-associated thrombotic microangiopathy (TA-TMA) are associated with excessive activation of the alternative complement pathway (AP) and with severe renal, but rarely cerebral, m
Autor:
Chengliang Zhu, Yong Lin, Zhongying Cao, Li Zhou, Haisheng Yu, Nanfang Peng, Xueyu Wang, Jun Wang, Shi Liu, Ying Zhu, Yinglong She, Mengqi Li, Qian Li, Xueyuan Chen, Mengji Lu
Publikováno v:
Journal of Biological Chemistry. 292:21291-21303
During influenza A virus (IAV) infection, cytokine storms play a vital and critical role in clinical outcomes. We have previously reported that microRNA (miR)-302c regulates IAV-induced IFN expression by targeting the 3′-UTR of nuclear factor κB (
Publikováno v:
Journal of Biological Chemistry. 292:14786-14795
Skin cancer is the most common cancer, and exposure to ultraviolet (UV) radiation, namely UVA and UVB, is the major risk factor for skin cancer development. UVA is significantly less effective in causing direct DNA damage than UVB, but UVA has been s
Autor:
Jérémie Sellam, Alain Sautet, Alice Courties, Marie-Charlotte Laiguillon, Carlos Vaamonde-Garcia, A. Pigenet, Xavier Houard, Francis Berenbaum, Saadia Kerdine-Römer, Rosa Meijide
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (35), pp.14505-14515. ⟨10.1074/jbc.M117.802157⟩
RUC. Repositorio da Universidade da Coruña
instname
Journal of Biological Chemistry, 2017, 292 (35), pp.14505-14515. ⟨10.1074/jbc.M117.802157⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (35), pp.14505-14515. ⟨10.1074/jbc.M117.802157⟩
RUC. Repositorio da Universidade da Coruña
instname
Journal of Biological Chemistry, 2017, 292 (35), pp.14505-14515. ⟨10.1074/jbc.M117.802157⟩
[Asbtract] Epidemiological findings support the hypothesis that type 2 diabetes mellitus (T2DM) is a risk factor for osteoarthritis (OA). Moreover, OA cartilage from patients with T2DM exhibits a greater response to inflammatory stress, but the molec
Autor:
Rakez Kayed
Publikováno v:
The Journal of Biological Chemistry
Alzheimer's disease (AD) is a devastating fatal neurodegenerative disease. An alternative to the amyloid cascade hypothesis is that a viral infection is key to the etiology of late-onset AD, with β-amyloid (Aβ) peptides playing a protective role. I
Autor:
Anindita Bhattacharya, Ashis Mukherjee, Kaushik Das, Shabbir A. Ansari, Ramesh Prasad, Suman Mallik, Prosenjit Sen, Abhishek Roy
Publikováno v:
Journal of Biological Chemistry. 292:13688-13701
Cell migration and invasion are very characteristic features of cancer cells that promote metastasis, which is one of the most common causes of mortality among cancer patients. Emerging evidence has shown that coagulation factors can directly mediate
Publikováno v:
Journal of Biological Chemistry. 292:12383-12389
Genetic and environmental factors contribute to the development of immune-mediated diseases. Although numerous genetic factors contributing to autoimmunity have been identified in recent years, our knowledge on environmental factors contributing to t
Autor:
Roger R. Markwald, Galina S. Bogatkevich, Ilia Atanelishvili, Richard M. Silver, Monika Gooz, Vincent C. Hascall, Shibnath Ghatak, Carol Feghali-Bostwick, Jeanette Marjorie Wood, Carol M. Artlett, Victor J. Thannickal, Suniti Misra
Publikováno v:
Journal of Biological Chemistry. 292:10490-10519
Idiopathic pulmonary fibrosis (IPF) is a progressive clinical syndrome of fatal outcome. The lack of information about the signaling pathways that sustain fibrosis and the myofibroblast phenotype has prevented the development of targeted therapies fo