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Publikováno v:
Journal of Biological Chemistry. 289:5250-5260
Neuronal restricted progenitors (NRPs) represent a type of transitional intermediate cells that lie between multipotent neural progenitors and terminal differentiated neurons during neurogenesis. These NRPs have the ability to self-renew and differen
Publikováno v:
Journal of Biological Chemistry. 289:529-539
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma found in children and young adults. It is characterized by the expression of a number of skeletal muscle-specific proteins, including MyoD and muscle α-actin. However, unlike normal myobl
Autor:
Josipa Bilic, Julian Pulecio, Marianna Vitaloni, Bernd Kuebler, Juan Carlos Izpisua Belmonte, Leopoldo Laricchia-Robbio
Publikováno v:
Journal of Biological Chemistry. 289:2084-2098
Induced pluripotent stem cells (iPSCs) maintain during the first few culture passages a set of epigenetic marks and metabolites characteristic of their somatic cell of origin, a concept defined as epigenetic donor memory. These residual somatic featu
Publikováno v:
Journal of Biological Chemistry. 289:747-764
Local production and action of cholesterol metabolites such as steroids or oxysterols within endocrine tissues are currently recognized as an important principle in the cell type- and tissue-specific regulation of hormone effects. In adipocytes, one
Publikováno v:
Journal of Biological Chemistry. 289:2526-2536
Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal lung disease characterized by the overgrowth, hardening, and scarring of lung tissue. The exact mechanisms of how IPF develops and progresses are unknown. IPF is characterized by extracellula
Publikováno v:
Journal of Biological Chemistry. 293:13349-13350
Obesity-induced metabolic dysfunctions increase the risk for vascular diseases, including type II diabetes and stroke. Managing obesity is of interest to address the worldwide health problem; however, the role of genetic variability in human obesity
Publikováno v:
Journal of Biological Chemistry. 288:37256-37266
The type III histone deacetylase Sirt1 has recently emerged as a critical immune regulator by suppressing T cell immunity and macrophage activation during inflammation, but its role in dendritic cells (DCs) remains unknown. Here, we show that mice wi
Autor:
Katharina Rimbach, Tatjana Eigenbrod, Marei Sammar, Frederik Marmé, Christian Rupp, Peter Altevogt, Anne-Kathleen Rupp, Niko P. Bretz, Ludmila Umansky, Viktor Umansky, Johannes Ridinger, Sascha Keller
Publikováno v:
Journal of Biological Chemistry. 288:36691-36702
Tumor-derived exosomes have been shown to induce various immunomodulatory effects. However, the underlying signaling pathways are poorly understood. Here, we analyzed the effects of ex vivo-derived exosomes on monocytic cell differentiation/activatio
Publikováno v:
Journal of Biological Chemistry. 288:36484-36491
Keratinocyte differentiation is a key process in the formation and maintenance of the protective skin barrier. Dysregulation in the balance of reactive oxygen species homeostasis may play a role in keratinocyte differentiation. We have identified the
Publikováno v:
Journal of Biological Chemistry. 288:34699-34706
Neurons undergo several morphological changes as a part of normal neuron maturation process. Alzheimer disease is associated with increased neuroproliferation and impaired neuronal maturation. In this study, we demonstrated that Gas7b (growth arrest