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Autor:
Mingyao Ying, Hugo Guerrero-Cazares, Jessica Tilghman, Yingying Wei, John Laterra, Alfredo Quiñones-Hinojosa, Hongkai Ji
Publikováno v:
Journal of Biological Chemistry. 289:32742-32756
It is increasingly important to understand the molecular basis for the plasticity of neoplastic cells and their capacity to transition between differentiated and stemlike phenotypes. Kruppel-like factor-9 (KLF9), a member of the large KLF transcripti
Publikováno v:
Journal of Biological Chemistry. 289:28433-28447
Circulating monocytes recruited to tissues can differentiate into macrophages and adopt unique gene expression programs in response to environmental cues. We recently described the regulated expression of several microRNAs (miRNAs) in polarized human
Publikováno v:
Journal of Biological Chemistry. 289:28225-28236
Odontoblasts are a type of terminally differentiated matrix-secreting cells. A number of molecular mechanisms are involved in the differentiation of odontoblasts. Several studies demonstrated that Krüppel-like factor 4 (KLF4) promotes odontoblast di
Publikováno v:
Journal of Biological Chemistry. 289:27327-27341
Pitx2, Wnt/β-catenin signaling, and microRNAs (miRs) play a critical role in the regulation of dental stem cells during embryonic development. In this report, we have identified a Pitx2:β-catenin regulatory pathway involved in epithelial cell diffe
Autor:
Qiang Wang, Christina Alidousty, Thomas Rauen, Tammo Ostendorf, Setareh Alampour-Rajabi, Jürgen Floege, Ute Raffetseder, Peter R. Mertens, Jürgen Bernhagen, Lydia Hanssen
Publikováno v:
Journal of Biological Chemistry. 289:21401-21412
Y-box (YB) protein-1 serves as a master regulator in gene transcription and mRNA translation. YB-1 itself is regulated at various levels, e.g. through post-translational modifications. In our previous work, we identified RANTES/CCL5 as a transcriptio
Publikováno v:
Journal of Biological Chemistry. 289:22048-22062
Sirtuin-1 (SIRT1), NAD(+)-dependent deacetylase, has been linked to anabolic effects in cartilage, although the mechanisms of SIRT1 signaling during differentiation of mesenchymal stem cells (MSCs) to chondrocytes are poorly understood. Therefore, we
Autor:
Masahiko Tanaka, Yasushi Date, Takaaki Yamada, Inoue Yu, Sadanori Ban, Hiroshi Mizutani, Seiji Hasegawa, Satoru Nakata, Naohide Hirashima
Publikováno v:
Journal of Biological Chemistry. 289:21451-21462
Zinc is essential for the proper functioning of various enzymes and transcription factors, and its homeostasis is rigorously controlled by zinc transporters (SLC39/ZIP, importers; SLC30/ZnT, exporters). Skin disease is commonly caused by a zinc defic
Autor:
Jin-Hui Wang, Chang Chen, Guang-Hui Liu, Linmin Liu, Wenting Su, Kaiyuan Wu, Tingting Yuan, Ruotong Ren, Yuying Zhang, Bo Wen, Juan Carlos Izpisua Belmonte, Fei Yi, Xinhua Qiao
Publikováno v:
Journal of Biological Chemistry. 289:20193-20199
Alcohol dehydrogenase 5 (ADH5) is a conserved enzyme for alcohol and aldehyde metabolism in mammals. Despite dynamic expression throughout neurogenesis, its role in neuronal development remains unknown. Here we present the first evidence that ADH5 is
Autor:
Michael Chopp, James J. Yang, Soumi Santra, Daniel C. Morris, Manoranjan Santra, Sutapa Santra, Zheng Gang Zhang
Publikováno v:
Journal of Biological Chemistry. 289:19508-19518
Thymosin β4 (Tβ4), a G-actin-sequestering peptide, improves neurological outcome in rat models of neurological injury. Tissue inflammation results from neurological injury, and regulation of the inflammatory response is vital for neurological recov
Autor:
Aida V. Estrada, Victor J. Thannickal, Guangjie Cheng, Yong Zhou, James F. Collawn, Qiang Ding, Leena P. Desai
Publikováno v:
Journal of Biological Chemistry. 289:18270-18278
Hydrogen peroxide-inducible clone 5 (Hic-5) is a focal adhesion adaptor protein induced by the profibrotic cytokine TGF-β1. We have demonstrated previously that TGF-β1 induces myofibroblast differentiation and lung fibrosis by activation of the rea