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Publikováno v:
J Biol Chem
Triple-negative breast cancer (TNBC) is an aggressive cancer subtype for which effective therapies are unavailable. TNBC has a high frequency of tumor protein p53 (Tp53/p53)- and phosphatase and tensin homolog (PTEN) deficiencies, and combined p53- a
Autor:
Takuya Tsumita, Mutsumi Inaba, Kota Sato, Jumpei Yamazaki, Benjaporn Kiatpakdee, Akito Yamamoto, Yayoi Otsuka, Narla Mohandas, Wataru Otsu, Reo Kawata, Yuqi Chen, Yoshikazu Sugimoto, Nobuto Arashiki, Kensuke Takada
Publikováno v:
The Journal of Biological Chemistry
TSPO2 (translocator protein 2) is a transmembrane protein specifically expressed in late erythroblasts and has been postulated to mediate intracellular redistribution of cholesterol. We identified TSPO2 as the causative gene for the HK (high-K+) trai
Autor:
Nithya Ramnath, Theodore S. Lawrence, Derek J. Nancarrow, Guoan Chen, Wenbin Ji, Dipankar Ray, Paramita Ray, Stefanie Galbán, Alnawaz Rehemtulla, Wei Huang, Zhuwen Wang, David G. Beer
Publikováno v:
J Biol Chem
We previously reported that overexpression of cytochrome P450 family 24 subfamily A member 1 (CYP24A1) increases lung cancer cell proliferation by activating RAS signaling and that CYP24A1 knockdown inhibits tumor growth. However, the mechanism of CY
Autor:
Yuanming He, Yuanying Zeng, Jiefei Tong, Biyin Cao, Michael F. Moran, Zubin Zhang, Siyu Wang, Ye Yang, Shuoyi Jiang, Yujia Xu, Xinliang Mao
Publikováno v:
J Biol Chem
The Maf proteins, including c-Maf, MafA, and MafB, are critical transcription factors in myelomagenesis. Previous studies demonstrated that Maf proteins are processed by the ubiquitin-proteasome pathway, but the mechanisms remain elusive. This study
Publikováno v:
J Biol Chem
MAF1 homolog, negative regulator of RNA polymerase III (MAF1) is a key repressor of RNA polymerase (pol) III-dependent transcription and functions as a tumor suppressor. Its expression is frequently down-regulated in primary human hepatocellular carc
Publikováno v:
J Biol Chem
An estimated 5.4 million cases of nonmelanoma skin cancer are reported in the United States at an associated cost of $4.8 billion. ΔNp63α, a proto-oncogene in the p53 family of transcription factors, is overexpressed in squamous cell carcinoma (SCC
Autor:
Nobumichi Ohoka, Muneshige Tokugawa, Hidetoshi Hayashi, Masayuki Komada, Yasumichi Inoue, Shin Watanabe, Daisuke Morishita, Chiharu Miyajima, Keishi Fukuura
Publikováno v:
J Biol Chem
Su(var)3–9, Enhancer-of-zeste, and Trithorax (SET) domain-containing protein 8 (SET8) is the sole enzyme that monomethylates Lys-20 of histone H4 (H4K20). SET8 has been implicated in the regulation of multiple biological processes, such as gene tra
Autor:
Manoj Kumar, Vivek Singh Tomar, Siddharth Singh, Tapas K. Kundu, Pawan Upadhyay, Sanjeev Kumar, M. Naveen, Amit Dutt, Sabita Roy, Shrinka Sen, Sayan Bhattacharjee
Publikováno v:
J Biol Chem
TP53 is the most frequently mutated tumor suppressor gene in many cancers, yet biochemical characterization of several of its reported mutations with probable biological significance have not been accomplished enough. Specifically, missense mutations
Publikováno v:
J Biol Chem
Ionizing radiation (IR) can promote migration and invasion of cancer cells, but the basis for this phenomenon has not been fully elucidated. IR increases expression of glucose-regulated protein 78kDa (GRP78) on the surface of cancer cells (CS-GRP78),
Autor:
Annika Herlemann, Christian Gratzke, Christian G. Stief, Beata Rutz, Raphaela Waidelich, Paul Kuppermann, Martin Hennenberg, Yiming Wang, Alexander Tamalunas, Anna Ciotkowska, Bingsheng Li, Xiaolong Wang, Qingfeng Yu, Frank Strittmatter, Ruixiao Wang
Publikováno v:
J Biol Chem
Voiding symptoms in benign prostatic hyperplasia (BPH) are driven by prostate smooth muscle contraction and prostate growth. Smooth muscle contraction in the prostate and other organs critically depends on activation of the small monomeric GTPase Rho