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Autor:
Naomi Kishine, Yoichi Tsumuraya, Naoki Sunagawa, Kiyohiko Igarashi, Masahiro Samejima, Toshihisa Kotake, Satoshi Kaneko, Kaori Matsuyama, Zui Fujimoto
Publikováno v:
Matsuyama, K, Kishine, N, Fujimoto, Z, Sunagawa, N, Kotake, T, Tsumuraya, Y, Samejima, M, Igarashi, K & Kaneko, S 2020, ' Unique active-site and subsite features in the arabinogalactan-degrading GH43 exo-β-1,3-galactanase from Phanerochaete chrysosporium. ', Journal of Biological Chemistry, vol. 295, no. 52, pp. 18539-18552 . https://doi.org/10.1074/jbc.RA120.016149
Arabinogalactan proteins (AGPs) are plant proteoglycans with functions in growth and development. However, these functions are largely unexplored, mainly because of the complexity of the sugar moieties. These carbohydrate sequences are generally anal
Autor:
James Wickens, Adam P. Hardy, Anthony Tumber, Martine I. Abboud, Michael A. McDonough, Christopher T. Lohans, Rasheduzzaman Chowdhury, Christopher M. West, Kerstin Lippl, Christopher J. Schofield, Elisabete Pires, Tongri Liu
Publikováno v:
The Journal of Biological Chemistry
In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate the levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist in other types of eukaryotes and prokaryotes where they act on n
Autor:
Marcelo Visona Liberato, Cheng-Jie Duan, Sergey A. Nepogodiev, Joe W. Gray, Arnaud Baslé, Robert A. Field, Didier Ndeh, Nathalie Juge
Publikováno v:
The Journal of Biological Chemistry
Pectins are a major dietary nutrient source for the human gut microbiota. The prominent gut microbe Bacteroides thetaiotaomicron was recently shown to encode the founding member (BT1017) of a new family of pectin methylesterases essential for the met
Autor:
Frederick P. Roth, Marc Vidal, Nozomu Yachie, Myungjin Jo, Sang Ryong Kim, Kyoungho Suk, Won-Ha Lee, Yeojin Seo, Hyejin Jeon, Quan Zhong, Jae-Hong Kim, Eun-Jung Kim, Donggun Seo, Young Seop Kim
Publikováno v:
J Biol Chem
Kinases are critical components of intracellular signaling pathways and have been extensively investigated with regard to their roles in cancer. p21-activated kinase-1 (PAK1) is a serine/threonine kinase that has been previously implicated in numerou
Autor:
Dimitry A. Svistunenko, Andrew M. Hemmings, Nick E. Le Brun, Geoffrey R. Moore, Michael T. Wilson, Justin M. Bradley
Publikováno v:
The Journal of Biological Chemistry
Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a growth-limiting factor. However, correct functioning of cells requires that the labile pool of chelatable “free” iron be tightly regulated. Correct m
Autor:
Thomas Piekut, Wassim Elkhatib, Adriano Senatore, Alicia N. Harracksingh, Julia Gauberg, Salsabil Abdallah, Elise F. Stanley
Publikováno v:
Journal of Biological Chemistry. 295:18553-18578
The dominant role of CaV2 voltage-gated calcium channels for driving neurotransmitter release is broadly conserved. Given the overlapping functional properties of CaV2 and CaV1 channels, and less so CaV3 channels, it is unclear why there have not bee
Autor:
Thomas M. Petro, Amy Lingel, Beka Solomon, Yuval Gavriel, Haishuang Lin, Yuguo Lei, Virginia Lopez, Pascal Polepole, Chi Zhang, Luwen Zhang, Eric A. Weaver
Publikováno v:
J Biol Chem
Zika virus (ZIKV) is a neurotropic flavivirus that causes several diseases including birth defects such as microcephaly. Intrinsic immunity is known to be a frontline defense against viruses through host anti-viral restriction factors. Limited knowle
Publikováno v:
The Journal of Biological Chemistry
Investigations of bacterial resistance strategies can aid in the development of new antimicrobial drugs as a countermeasure to the increasing worldwide prevalence of bacterial antibiotic resistance. One such strategy involves the TipA class of transc
Publikováno v:
The Journal of Biological Chemistry
Reactive oxygen species (ROS) are an unavoidable host environmental cue for intracellular pathogens such as Mycobacterium tuberculosis and Mycobacterium bovis; however, the signaling pathway in mycobacteria for sensing and responding to environmental
Autor:
Ke-Qin Zhang, Yuhong Li, Hua Bai, Wei Zou, Xiaowei Huang, Ninghui Zhao, Jinyuan Yan, Zhongshan Yang
Publikováno v:
J Biol Chem
Recent studies have suggested that innate immune responses exhibit characteristics associated with memory linked to modulations in both vertebrates and invertebrates. However, the diverse evolutionary paths taken, particularly within the invertebrate