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Autor:
Thomas M. Petro, Amy Lingel, Beka Solomon, Yuval Gavriel, Haishuang Lin, Yuguo Lei, Virginia Lopez, Pascal Polepole, Chi Zhang, Luwen Zhang, Eric A. Weaver
Publikováno v:
J Biol Chem
Zika virus (ZIKV) is a neurotropic flavivirus that causes several diseases including birth defects such as microcephaly. Intrinsic immunity is known to be a frontline defense against viruses through host anti-viral restriction factors. Limited knowle
Autor:
Sukanya Chakravarty, R. Travis Taylor, Sonam Popli, Gayatri Subramanian, Saurabh Chattopadhyay, Ritu Chakravarti
Publikováno v:
J Biol Chem
The interferon system is the first line of defense against virus infection. Recently, using a high-throughput genetic screen of a human interferon-stimulated gene short-hairpin RNA library, we identified a viral restriction factor, TDRD7 (Tudor domai
Autor:
Yue-Yi Wang, Aifu Lin, Jian-Zhong Shao, Tong Shao, Li-Xin Xiang, Dong-Dong Fan, Jiang-yuan Li
Publikováno v:
J Biol Chem
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is one of the best-characterized inflammasomes in humans and other mammals. However, knowledge about the NLRP3 inflammasome in nonmammalian species remains limited. Here, we report the mol
Publikováno v:
Journal of Biological Chemistry. 295:1195-1201
Pseudomonas aeruginosa is an extracellular opportunistic bacterial pathogen commonly associated with infectious complications in susceptible individuals, such as those with underlying diseases including HIV/AIDS and cystic fibrosis. Antibiotic resist
Autor:
Kwang-Hee Lee, David C Gemperline, Qingzhen Zhao, Fionn McLoughlin, Richard S. Marshall, Weiming Hu, Mark Scalf, Lloyd M. Smith, Richard D. Vierstra
Publikováno v:
Journal of Biological Chemistry. 294:17570-17592
The 26S proteasome is an essential protease that selectively eliminates dysfunctional and short-lived regulatory proteins in eukaryotes. To define the composition of this proteolytic machine in plants, we tagged either the core protease (CP) or the r
Publikováno v:
Journal of Biological Chemistry. 294:16765-16775
Epithelial Na+ channel (ENaC)-mediated Na+ transport has a key role in the regulation of extracellular fluid volume, blood pressure, and extracellular [K+]. Among the thousands of human ENaC variants, only a few exist whose functional consequences ha
Autor:
Aditya Dandekar, Tshifhiwa Magoro, Angelina R. Angelucci, Young S. Hahn, Gabriel Lipkowitz, Lucas T. Jennelle, Rohan Bajaj, Pascal O. Bessong
Publikováno v:
J Biol Chem
Zika virus (ZIKV)(3) is an enveloped, single-stranded, positive-sense RNA virus of the Flaviviridae family that has emerged as a public health threat because of its global transmission and link to microcephaly. Currently there is no vaccine for this
Autor:
Santosh Kumar, Ved Prakash Dwivedi, Sandeep Rai Kaushik, Ankur Kulshreshtha, Gobardhan Das, Shivam Chaturvedi, Chetan Sharma, Ashima Bhaskar, Debprasad Chattopadhyay, Ranjan Kumar Nanda
Publikováno v:
J Biol Chem
The widespread availability and use of modern synthetic therapeutic agents have led to a massive decline in ethnomedical therapies. However, these synthetic agents often possess toxicity leading to various adverse effects. For instance, anti-tubercul
Autor:
Dibyendu Dutta, Sunanda Bhattacharyya, Pratap Vydyam, Niranjan Sutram, Mrinal Kanti Bhattacharyya
Publikováno v:
Journal of Biological Chemistry. 294:8171-8183
Malaria parasites repair DNA double-strand breaks (DSBs) primarily through homologous recombination (HR). Here, because the unrepaired DSBs lead to the death of the unicellular parasite Plasmodium falciparum, we investigated its recombinase, PfRad51,
ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp
Publikováno v:
Journal of Biological Chemistry. 294:7787-7796
Platelet factor 4 (PF4) is an anti-Plasmodium component of platelets. It is expressed in megakaryocytes and released from platelets following infection with Plasmodium. Innate immunity is crucial for the host anti-Plasmodium response, in which type I